Seroatlas · Human Serome Atlas

DCAKD

Dephospho-CoA kinase domain-containing protein

Also known as: DCAKD_HUMAN, FLJ22955

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVC6
Gene: DCAKD
Ensembl: ENSG00000172992
Chromosome: 17
Canonical length: 231 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>Q8WVC6|DCAKD
     1  MFLVGLTGGI ASGKSSVIQV FQQLGCAVID VDVMARHVVQ PGYPAHRRIV EVFGTEVLLE
    61  NGDINRKVLG DLIFNQPDRR QLLNAITHPE IRKEMMKETF KYFLRGYRYV ILDIPLLFET
   121  KKLLKYMKHT VVVYCDRDTQ LARLMRRNSL NRKDAEARIN AQLPLTDKAR MARHVLDNSG
   181  EWSVTKRQVI LLHTELERSL EYLPLRFGVL TGLAAIASLL YLLTHYLLPY A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAKD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

midbrain: 39 nTPM
basal ganglia: 35 nTPM
hypothalamus: 35 nTPM
cerebral cortex: 32 nTPM
salivary gland: 31 nTPM
spinal cord: 31 nTPM

Single-cell type

cone photoreceptor cells: 124 nCPM
choroid plexus epithelial cells: 116 nCPM
ocular epithelial cells: 80 nCPM
ependymal cells: 73 nCPM
prostatic hillock cells: 70 nCPM
rod photoreceptor cells: 70 nCPM

Immune cell

plasmacytoid DC: 8.8 nTPM
MAIT T-cell: 7.9 nTPM
memory CD4 T-cell: 6.1 nTPM
myeloid DC: 6.1 nTPM
T-reg: 5.9 nTPM
gdT-cell: 5.3 nTPM

Brain region

medulla oblongata: 119 nTPM
midbrain: 108 nTPM
spinal cord: 103 nTPM
hypothalamus: 103 nTPM
white matter: 102 nTPM
thalamus: 101 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DCAKD.

Disease | ImmuneIEDB

Conditions an epitope on DCAKD was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.06
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

coenzyme A biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAKD as an antibody target. Whether an autoantibody or antibody against DCAKD could matter depends on whether native DCAKD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAKD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAKD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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