Seroatlas · Human Serome Atlas

GEM

GTP-binding protein GEM

Also known as: GEM_HUMAN, KIR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55040
Gene: GEM
Ensembl: ENSG00000164949
Chromosome: 8
Canonical length: 296 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>P55040|GEM
     1  MTLNNVTMRQ GTVGMQPQQQ RWSIPADGRH LMVQKEPHQY SHRNRHSATP EDHCRRSWSS
    61  DSTDSVISSE SGNTYYRVVL IGEQGVGKST LANIFAGVHD SMDSDCEVLG EDTYERTLMV
   121  DGESATIILL DMWENKGENE WLHDHCMQVG DAYLIVYSIT DRASFEKASE LRIQLRRARQ
   181  TEDIPIILVG NKSDLVRCRE VSVSEGRACA VVFDCKFIET SAAVQHNVKE LFEGIVRQVR
   241  LRRDSKEKNE RRLAYQKRKE SMPRKARRFW GKIVAKNNKN MAFKLKSKSC HDLSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GEM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 215 nTPM

Expression across tissuesHPA

Tissue

gallbladder: 215 nTPM
blood vessel: 160 nTPM
colon: 103 nTPM
endometrium: 91 nTPM
urinary bladder: 85 nTPM
smooth muscle: 72 nTPM

Single-cell type

smooth muscle cells: 414 nCPM
fibroblasts: 402 nCPM
retinal pigment epithelial cells: 401 nCPM
pericytes: 372 nCPM
vascular smooth muscle cells: 335 nCPM
decidual stromal cells: 292 nCPM

Immune cell

myeloid DC: 1.4 nTPM
T-reg: 0.2 nTPM
NK-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 70 nTPM
hypothalamus: 35 nTPM
medulla oblongata: 17 nTPM
thalamus: 16 nTPM
midbrain: 16 nTPM
cerebral cortex: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GEM as an antibody target. Whether an autoantibody or antibody against GEM could matter depends on whether native GEM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GEM is annotated at the cell surface, where native GEM is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GEM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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