Seroatlas · Human Serome Atlas

ZNG1F

Zinc-regulated GTPase metalloprotein activator 1F

Also known as: CBWD6, CBWD7, ZNG1F_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4V339
Gene: ZNG1F
Ensembl: ENSG00000215126
Chromosome: 9
Canonical length: 395 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable GTP binding activity; hydrolase activity; and metal ion binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q4V339|ZNG1F
     1  MLPAVGSVDE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN
    61  YILTEQHSKR VAVILNESGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI
   121  ENLMQKKGKF DDILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLTE
   181  EKPDGLINEA TRQVALADII LINKTDLVPE EDVKKLRTTL RSINGLGQIL ETQRSRVDLS
   241  NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFD VPGNAKEEHL NMFIQNLLWE
   301  KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELCDL EETPVSWKDD TERTNRLVLI
   361  GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNG1F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

liver: 6.3 nTPM
adrenal gland: 4.8 nTPM
kidney: 3.6 nTPM
skeletal muscle: 3.4 nTPM
pancreas: 3.3 nTPM
esophagus: 2.9 nTPM

Single-cell type

late spermatids: 41 nCPM
suprabasal keratinocytes: 24 nCPM
basal keratinocytes: 24 nCPM
early spermatids: 24 nCPM
adrenal medulla cells: 21 nCPM
papillary tip epithelial cells: 21 nCPM

Immune cell

non-classical monocyte: 7.1 nTPM
intermediate monocyte: 5.1 nTPM
classical monocyte: 4.2 nTPM
memory B-cell: 3.5 nTPM
memory CD4 T-cell: 3 nTPM
plasmacytoid DC: 2.7 nTPM

Brain region

choroid plexus: 1.6 nTPM
pons: 0.9 nTPM
hypothalamus: 0.8 nTPM
cerebral cortex: 0.6 nTPM
thalamus: 0.6 nTPM
medulla oblongata: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNG1F as an antibody target. Whether an autoantibody or antibody against ZNG1F could matter depends on whether native ZNG1F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNG1F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNG1F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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