Seroatlas · Human Serome Atlas

MYO5C

Unconventional myosin-Vc

Also known as: MGC74969, MYO5C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQX4
Gene: MYO5C
Ensembl: ENSG00000128833
Chromosome: 15
Canonical length: 1742 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1742 residues, UniProt reviewed canonical sequence.

>Q9NQX4|MYO5C
     1  MAVAELYTQY NRVWIPDPEE VWKSAEIAKD YRVGDKVLRL LLEDGTELDY SVNPESLPPL
    61  RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY SGIILVAMNP YKQLPIYGDA
   121  IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR NNRNQSIIVS GESGAGKTVS ARYAMRYFAT
   181  VSKSGSNAHV EDKVLASNPI TEAVGNAKTT RNDNSSRFGK YTEISFDEQN QIIGANMSTY
   241  LLEKSRVVFQ SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG NTVIEGVNDR
   301  AEMVETQKTF TLLGFKEDFQ MDVFKILAAI LHLGNVQITA VGNERSSVSE DDSHLKVFCE
   361  LLGLESGRVA QWLCNRKIVT SSETVVKPMT RPQAVNARDA LAKKIYAHLF DFIVERINQA
   421  LQFSGKQHTF IGVLDIYGFE TFDVNSFEQF CINYANEKLQ QQFNMHVFKL EQEEYMKEDI
   481  PWTLIDFYDN QPVIDLIEAK MGILELLDEE CLLPHGTDEN WLQKLYNNFV NRNPLFEKPR
   541  MSNTSFVIQH FADKVEYKCE GFLEKNRDTV YDMLVEILRA SKFHLCANFF QENPTPPSPF
   601  GSMITVKSAK QVIKPNSKHF RTTVGSKFRS SLYLLMETLN ATTPHYVRCI KPNDEKLPFE
   661  FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYIEFYSRYG ILMTKQELSF SDKKEVCKVV
   721  LHRLIQDSNQ YQFGKTKIFF RAGQVAYLEK LRLDKLRQSC VMVQKHMRGW LQRKKFLRER
   781  RAALIIQQYF RGQQTVRKAI TAVALKEAWA AIIIQKHCRG YLVRSLYQLI RMATITMQAY
   841  SRGFLARRRY RKMLEEHKAV ILQKYARAWL ARRRFQSIRR FVLNIQLTYR VQRLQKKLED
   901  QNKENHGLVE KLTSLAALRA GDVEKIQKLE AELEKAATHR RNYEEKGKRY RDAVEEKLAK
   961  LQKHNSELET QKEQIQLKLQ EKTEELKEKM DNLTKQLFDD VQKEERQRML LEKSFELKTQ
  1021  DYEKQIQSLK EEIKALKDEK MQLQHLVEGE HVTSDGLKAE VARLSKQVKT ISEFEKEIEL
  1081  LQAQKIDVEK HVQSQKREMR EKMSEITKQL LESYDIEDVR SRLSVEDLEH LNEDGELWFA
  1141  YEGLKKATRV LESHFQSQKD CYEKEIEALN FKVVHLSQEI NHLQKLFREE NDINESIRHE
  1201  VTRLTSENMM IPDFKQQISE LEKQKQDLEI RLNEQAEKMK GKLEELSNQL HRSQEEEGTQ
  1261  RKALEAQNEI HTKEKEKLID KIQEMQEASD HLKKQFETES EVKCNFRQEA SRLTLENRDL
  1321  EEELDMKDRV IKKLQDQVKT LSKTIGKAND VHSSSGPKEY LGMLQYKRED EAKLIQNLIL
  1381  DLKPRGVVVN MIPGLPAHIL FMCVRYADSL NDANMLKSLM NSTINGIKQV VKEHLEDFEM
  1441  LSFWLSNTCH FLNCLKQYSG EEEFMKHNSP QQNKNCLNNF DLSEYRQILS DVAIRIYHQF
  1501  IIIMEKNIQP IIVPGMLEYE SLQGISGLKP TGFRKRSSSI DDTDGYTMTS VLQQLSYFYT
  1561  TMCQNGLDPE LVRQAVKQLF FLIGAVTLNS LFLRKDMCSC RKGMQIRCNI SYLEEWLKDK
  1621  NLQNSLAKET LEPLSQAAWL LQVKKTTDSD AKEIYERCTS LSAVQIIKIL NSYTPIDDFE
  1681  KRVTPSFVRK VQALLNSRED SSQLMLDTKY LFQVTFPFTP SPHALEMIQI PSSFKLGFLN
  1741  RL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO5C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

pancreas: 26 nTPM
salivary gland: 20 nTPM
stomach: 18 nTPM
thyroid gland: 17 nTPM
rectum: 17 nTPM
cervix: 13 nTPM

Single-cell type

alveolar cells type 1: 289 nCPM
respiratory deuterosomal cells: 262 nCPM
foveolar cells: 224 nCPM
transitional alveolar cells: 191 nCPM
respiratory secretory cells: 190 nCPM
alveolar cells type 2: 183 nCPM

Immune cell

T-reg: 0.7 nTPM
neutrophil: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
memory B-cell: 0.2 nTPM
myeloid DC: 0.2 nTPM
gdT-cell: 0.1 nTPM

Brain region

choroid plexus: 36 nTPM
cerebellum: 16 nTPM
spinal cord: 15 nTPM
medulla oblongata: 13 nTPM
white matter: 12 nTPM
pons: 7.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MYO5C.

Disease | ImmuneIEDB

Conditions an epitope on MYO5C was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYO5C as an antibody target. Whether an autoantibody or antibody against MYO5C could matter depends on whether native MYO5C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYO5C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYO5C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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