Seroatlas · Human Serome Atlas

UCK1

Uridine-cytidine kinase 1

Also known as: FLJ12255, UCK1_HUMAN, URK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HA47
Gene: UCK1
Ensembl: ENSG00000130717
Chromosome: 9
Canonical length: 277 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>Q9HA47|UCK1
     1  MASAGGEDCE SPAPEADRPH QRPFLIGVSG GTASGKSTVC EKIMELLGQN EVEQRQRKVV
    61  ILSQDRFYKV LTAEQKAKAL KGQYNFDHPD AFDNDLMHRT LKNIVEGKTV EVPTYDFVTH
   121  SRLPETTVVY PADVVLFEGI LVFYSQEIRD MFHLRLFVDT DSDVRLSRRV LRDVRRGRDL
   181  EQILTQYTTF VKPAFEEFCL PTKKYADVII PRGVDNMVAI NLIVQHIQDI LNGDICKWHR
   241  GGSNGRSYKR TFSEPGDHPG MLTSGKRSHL ESSSRPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

liver: 52 nTPM
cerebellum: 50 nTPM
skeletal muscle: 42 nTPM
basal ganglia: 38 nTPM
amygdala: 38 nTPM
cerebral cortex: 37 nTPM

Single-cell type

late spermatids: 51 nCPM
esophageal apical cells: 49 nCPM
cytotrophoblasts: 39 nCPM
hofbauer cells: 39 nCPM
early primary spermatocytes: 38 nCPM
migrating cytotrophoblasts: 38 nCPM

Immune cell

T-reg: 12 nTPM
naive CD4 T-cell: 11 nTPM
MAIT T-cell: 9.8 nTPM
eosinophil: 9 nTPM
memory CD4 T-cell: 8.6 nTPM
naive B-cell: 8.1 nTPM

Brain region

thalamus: 29 nTPM
midbrain: 28 nTPM
medulla oblongata: 28 nTPM
basal ganglia: 26 nTPM
spinal cord: 26 nTPM
white matter: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.83
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UCK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UCK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UCK1 as an antibody target. Whether an autoantibody or antibody against UCK1 could matter depends on whether native UCK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UCK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UCK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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