Seroatlas · Human Serome Atlas

RAB3C

Ras-related protein Rab-3C

Also known as: RAB3C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96E17
Gene: RAB3C
Ensembl: ENSG00000152932
Chromosome: 5
Canonical length: 227 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene is a member of the RAS oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q96E17|RAB3C
     1  MRHEAPMQMA SAQDARYGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY ADDSFTSAFV
    61  STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY RGAMGFILMY DITNEESFNA
   121  VQDWSTQIKT YSWDNAQVIL VGNKCDMEDE RVISTERGQH LGEQLGFEFF ETSAKDNINV
   181  KQTFERLVDI ICDKMSESLE TDPAITAAKQ NTRLKETPPP PQPNCAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 32 nTPM
hypothalamus: 27 nTPM
basal ganglia: 17 nTPM
midbrain: 16 nTPM
amygdala: 11 nTPM
hippocampal formation: 11 nTPM

Single-cell type

corticotrophs: 615 nCPM
other brain neurons: 601 nCPM
brain inhibitory neurons: 417 nCPM
neuroendocrine cells: 374 nCPM
lactotrophs: 301 nCPM
adrenal medulla cells: 255 nCPM

Immune cell

eosinophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 185 nTPM
cerebral cortex: 114 nTPM
pons: 110 nTPM
thalamus: 81 nTPM
basal ganglia: 81 nTPM
midbrain: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 1.26
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB3C as an antibody target. Whether an autoantibody or antibody against RAB3C could matter depends on whether native RAB3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB3C is annotated at the cell surface, where native RAB3C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...