Seroatlas · Human Serome Atlas

ZNG1B

Zinc-regulated GTPase metalloprotein activator 1B

Also known as: CBWD2, ZNG1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUF1
Gene: ZNG1B
Ensembl: ENSG00000136682
Chromosome: 2
Canonical length: 395 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable GTP binding activity; hydrolase activity; and metal ion binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q8IUF1|ZNG1B
     1  MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN
    61  YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI
   121  ENLMQKKGKF DYILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLAE
   181  EKPDGLINEA TRQVALADAI LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS
   241  NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
   301  KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLL
   361  GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNG1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

tongue: 21 nTPM
skeletal muscle: 17 nTPM
parathyroid gland: 15 nTPM
heart muscle: 11 nTPM
kidney: 9 nTPM
cerebellum: 8.7 nTPM

Single-cell type

suprabasal keratinocytes: 80 nCPM
sertoli cells: 75 nCPM
basal keratinocytes: 74 nCPM
early primary spermatocytes: 68 nCPM
epididymal principal cells: 63 nCPM
cone photoreceptor cells: 58 nCPM

Immune cell

classical monocyte: 15 nTPM
myeloid DC: 15 nTPM
total PBMC: 12 nTPM
eosinophil: 12 nTPM
intermediate monocyte: 11 nTPM
non-classical monocyte: 8.6 nTPM

Brain region

choroid plexus: 3.6 nTPM
cerebellum: 1.4 nTPM
hippocampal formation: 1.3 nTPM
cerebral cortex: 1.2 nTPM
hypothalamus: 1 nTPM
midbrain: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.01
DepMap mean gene effect: -0.68
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNG1B as an antibody target. Whether an autoantibody or antibody against ZNG1B could matter depends on whether native ZNG1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNG1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNG1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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