Seroatlas · Human Serome Atlas

SEPTIN8

Septin-8

Also known as: KIAA0202, SEP2, SEPT8, SEPT8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92599
Gene: SEPTIN8
Ensembl: ENSG00000164402
Chromosome: 5
Canonical length: 483 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Primary cilium,Cytosol,Mid piece,Principal piece,Annulus

OverviewNCBI Gene

This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>Q92599|SEPTIN8
     1  MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL
    61  MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDESYRPI
   121  VDYIDAQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN
   181  IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV
   241  GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY
   301  RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK
   361  EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP
   421  LRKDKDKKNR SDIGAHQPGM SLSSSKVMMT KASVEPLNCS SWWPAIQCCS CLVRDATWRE
   481  GFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEPTIN8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 750 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 750 nTPM
midbrain: 354 nTPM
hippocampal formation: 252 nTPM
amygdala: 193 nTPM
basal ganglia: 184 nTPM
hypothalamus: 175 nTPM

Single-cell type

oligodendrocytes: 185 nCPM
retinal horizontal cells: 152 nCPM
müller glia: 123 nCPM
bergmann glia: 119 nCPM
oligodendrocyte progenitor cells: 108 nCPM
retinal pigment epithelial cells: 90 nCPM

Immune cell

memory CD8 T-cell: 2.5 nTPM
gdT-cell: 2 nTPM
MAIT T-cell: 2 nTPM
T-reg: 1.9 nTPM
memory CD4 T-cell: 1.6 nTPM
myeloid DC: 1.2 nTPM

Brain region

white matter: 627 nTPM
medulla oblongata: 501 nTPM
cerebellum: 414 nTPM
pons: 410 nTPM
basal ganglia: 392 nTPM
midbrain: 376 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.08
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEPTIN8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEPTIN8 as an antibody target. Whether an autoantibody or antibody against SEPTIN8 could matter depends on whether native SEPTIN8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEPTIN8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEPTIN8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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