Seroatlas · Human Serome Atlas

PSTK

L-seryl-tRNA(Sec) kinase

Also known as: C10orf89, MGC35392, PSTK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IV42
Gene: PSTK
Ensembl: ENSG00000179988
Chromosome: 10
Canonical length: 348 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoli,Nuclear bodies,Actin filaments

OverviewNCBI Gene

Predicted to enable kinase activity and tRNA binding activity. Predicted to be involved in translation. Predicted to act upstream of or within selenocysteine incorporation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q8IV42|PSTK
     1  MKTAENIRGT GSDGPRKRGL CVLCGLPAAG KSTFARALAH RLQQEQGWAI GVVAYDDVMP
    61  DAFLAGARAR PAPSQWKLLR QELLKYLEYF LMAVINGCQM SVPPNRTEAM WEDFITCLKD
   121  QDLIFSAAFE AQSCYLLTKT AVSRPLFLVL DDNFYYQSMR YEVYQLARKY SLGFCQLFLD
   181  CPLETCLQRN GQRPQALPPE TIHLMGRKLE KPNPEKNAWE HNSLTIPSPA CASEASLEVT
   241  DLLLTALENP VKYAEDNMEQ KDTDRIICST NILHKTDQTL RRIVSQTMKE AKGNQEAFSE
   301  MTFKQRWVRA NHAAIWRIIL GNEHIKCRSA KVGWLQCCRI EKRPLSTG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSTK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 5.8 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.8 nTPM
liver: 3.9 nTPM
skeletal muscle: 3.4 nTPM
spinal cord: 3.4 nTPM
epididymis: 3.3 nTPM
cerebral cortex: 3 nTPM

Single-cell type

oocytes: 124 nCPM
late primary spermatocytes: 88 nCPM
somatotrophs: 50 nCPM
cardiomyocytes: 48 nCPM
thyrotrophs: 42 nCPM
undifferentiated spermatogonia: 39 nCPM

Immune cell

MAIT T-cell: 8.8 nTPM
naive CD8 T-cell: 7.7 nTPM
naive CD4 T-cell: 7.5 nTPM
gdT-cell: 7.4 nTPM
memory CD8 T-cell: 7 nTPM
myeloid DC: 6.8 nTPM

Brain region

white matter: 6.4 nTPM
pons: 5.8 nTPM
medulla oblongata: 4 nTPM
cerebellum: 3.7 nTPM
hypothalamus: 3.7 nTPM
basal ganglia: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: -0.49
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

translation

Molecular functions

ATP binding
kinase activity
tRNA binding
L-seryl-tRNA(Sec) kinase activity

Protein domainsUniProt · Pfam · InterPro

Protein KTI12/L-seryl-tRNA(Sec) kinase
P-loop containing nucleoside triphosphate hydrolase
Chromatin associated protein KTI12
L-seryl-tRNA(Sec)kinase, eukaryote
L-seryl-tRNA(Sec) kinase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSTK as an antibody target. Whether an autoantibody or antibody against PSTK could matter depends on whether native PSTK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSTK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSTK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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