Seroatlas · Human Serome Atlas

SULT6B1

Sulfotransferase 6B1

Also known as: ST6B1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IMI4
Gene: SULT6B1
Ensembl: ENSG00000138068
Chromosome: 2
Canonical length: 303 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable sulfotransferase activity. Predicted to be involved in sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q6IMI4|SULT6B1
     1  MADKSKFIEY IDEALEKSKE TALSHLFFTY QGIPYPITMC TSETFQALDT FEARHDDIVL
    61  ASYPKCGSNW ILHIVSELIY AVSKKKYKYP EFPVLECGDS EKYQRMKGFP SPRILATHLH
   121  YDKLPGSIFE NKAKILVIFR NPKDTAVSFL HFHNDVPDIP SYGSWDEFFR QFMKGQVSWG
   181  RYFDFAINWN KHLDGDNVKF ILYEDLKENL AAGIKQIAEF LGFFLTGEQI QTISVQSTFQ
   241  AMRAKSQDTH GAVGPFLFRK GEVGDWKNLF SEIQNQEMDE KFKECLAGTS LGAKLKYESY
   301  CQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT6B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 1.8 nTPM

Expression across tissuesHPA

Tissue

testis: 1.8 nTPM
bone marrow: 0.3 nTPM
esophagus: 0.2 nTPM
basal ganglia: 0.1 nTPM
fallopian tube: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

late primary spermatocytes: 41 nCPM
early spermatids: 9.3 nCPM
paneth cells: 7.7 nCPM
late spermatids: 6.8 nCPM
thymic myoid cells: 5.4 nCPM
respiratory ionocytes: 5.1 nCPM

Immune cell

basophil: 1.6 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 1.7 nTPM
cerebral cortex: 1.4 nTPM
pons: 1.2 nTPM
thalamus: 1 nTPM
hippocampal formation: 0.9 nTPM
amygdala: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -0.71
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

sulfation

Molecular functions

sulfotransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT6B1 as an antibody target. Whether an autoantibody or antibody against SULT6B1 could matter depends on whether native SULT6B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT6B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT6B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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