Seroatlas · Human Serome Atlas

RASL10A

Ras-like protein family member 10A

Also known as: RRP22, RSLAA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92737
Gene
RASL10A
Ensembl
ENSG00000100276
Chromosome
22
Canonical length
203 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in nucleolus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>Q92737|RASL10A
     1  MGGSLRVAVL GAPGVGKTAI IRQFLFGDYP ERHRPTDGPR LYRPAVLLDG AVYDLSIRDG
    61  DVAGPGSSPG GPEEWPDAKD WSLQDTDAFV LVYDICSPDS FDYVKALRQR IAETRPAGAP
   121  EAPILVVGNK RDRQRLRFGP RRALAALVRR GWRCGYLECS AKYNWHVLRL FRELLRCALV
   181  RARPAHPALR LQGALHPARC SLM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASL10A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 39 nTPM
  • cerebral cortex: 31 nTPM
  • hippocampal formation: 29 nTPM
  • basal ganglia: 24 nTPM
  • hypothalamus: 18 nTPM
  • midbrain: 13 nTPM

Single-cell type

  • oocytes: 55 nCPM
  • astrocytes: 47 nCPM
  • breast secretory cells: 39 nCPM
  • brain excitatory neurons: 31 nCPM
  • myosatellite cells: 23 nCPM
  • microglia: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 53 nTPM
  • amygdala: 47 nTPM
  • basal ganglia: 39 nTPM
  • hippocampal formation: 35 nTPM
  • white matter: 26 nTPM
  • thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0.18
gnomAD missense Z
1.68
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASL10A as an antibody target. Whether an autoantibody or antibody against RASL10A could matter depends on whether native RASL10A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASL10A is annotated at the cell surface, where native RASL10A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RASL10A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RASL10A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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