MYO3B

Protein identityUniProt · HPA

UniProt accession

Q8WXR4

Gene

MYO3B

Ensembl

ENSG00000071909

Chromosome

2

Canonical length

1341 aa

Protein class

Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

1341 residues, UniProt reviewed canonical sequence.

>Q8WXR4|MYO3B
     1  MKHLYGLFHY NPMMLGLESL PDPTDTWEII ETIGKGTYGK VYKVTNKRDG SLAAVKILDP
    61  VSDMDEEIEA EYNILQFLPN HPNVVKFYGM FYKADHCVGG QLWLVLELCN GGSVTELVKG
   121  LLRCGQRLDE AMISYILYGA LLGLQHLHNN RIIHRDVKGN NILLTTEGGV KLVDFGVSAQ
   181  LTSTRLRRNT SVGTPFWMAP EVIACEQQYD SSYDARCDVW SLGITAIELG DGDPPLFDMH
   241  PVKTLFKIPR NPPPTLLHPE KWCEEFNHFI SQCLIKDFER RPSVTHLLDH PFIKGVHGKV
   301  LFLQKQLAKV LQDQKHQNPV AKTRHERMHT RRPYHVEDAE KYCLEDDLVN LEVLDEDTII
   361  HQLQKRYADL LIYTYVGDIL IALNPFQNLS IYSPQFSRLY HGVKRASNPP HIFASADAAY
   421  QCMVTLSKDQ CIVISGESGS GKTESAHLIV QHLTFLGKAN NQTLREKILQ VNSLVEAFGN
   481  SCTAINDNSS RFGKYLEMMF TPTGVVMGAR ISEYLLEKSR VIKQAAREKN FHIFYYIYAG
   541  LHHQKKLSDF RLPEEKPPRY IADETGRVMH DITSKESYRR QFEAIQHCFR IIGFTDKEVH
   601  SVYRILAGIL NIGNIEFAAI SSQHQTDKSE VPNAEALQNA ASVLCISPEE LQEALTSHCV
   661  VTRGETIIRA NTVDRAADVR DAMSKALYGR LFSWIVNRIN TLLQPDENIC SAGGGMNVGI
   721  LDIFGFENFQ RNSFEQLCIN IANEQIQYYF NQHVFALEQM EYQNEGIDAV PVEYEDNRPL
   781  LDMFLQKPLG LLALLDEESR FPQATDQTLV DKFEDNLRCK YFWRPKGVEL CFGIQHYAGK
   841  VLYDASGVLE KNRDTLPADV VVVLRTSENK LLQQLFSIPL TKTGNLAQTR ARITVASSSL
   901  PPHFSAGKAK VDTLEVIRHP EETTNMKRQT VASYFRYSLM DLLSKMVVGQ PHFVRCIKPN
   961  DDREALQFSR ERVLAQLRST GILETVSIRR QGYSHRILFE EFVKRYYYLA FTAHQTPLAS
  1021  KESCVAILEK SRLDHWVLGK TKVFLKYYHV EQLNLLLREV IGRVVVLQAY TKGWLGARRY
  1081  KRVREKREKG AIAIQSAWRG YDARRKFKKI SNRRNESAAH NQAGDTSNQS SGPHSPVAAG
  1141  TRGSAEVQDC SEPGDHKVLR GSVHRRSHSQ AESNNGRTQT SSNSPAVTEK NGHSQAQSSP
  1201  KGCDIFAGHA NKHSVSGTDL LSSRICHPAP DQQGLSLWGA PQKPGSENGL AQKHRTPRRR
  1261  CQQPKMLSSP EDTMYYNQLN GTLEYQGSKR KPRKLGQIKV LDGEDEYYKS LSPVDCIPEE
  1321  NNSAHPSFFS SSSKGDSFAQ H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYO3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

13 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.99

gnomAD pLI

0

gnomAD missense Z

0.11

DepMap mean gene effect

-0.16

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cochlea morphogenesis
• positive regulation of filopodium assembly
• regulation of actin filament length
• sensory perception of sound
• visual perception

Molecular functions

• actin binding
• ATP binding
• microfilament motor activity
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• cytoplasm
• filopodium tip
• myosin complex
• photoreceptor inner segment
• stereocilium tip

Protein domainsUniProt · Pfam · InterPro

• IQ motif, EF-hand binding site
• Protein kinase domain
• Myosin head, motor domain-like
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• P-loop containing nucleoside triphosphate hydrolase
• Class III myosin, motor domain
• Kinesin motor domain superfamily
• Myosin-III family with kinase activity
• Myosin head (motor domain)
• Protein kinase domain
• IQ calmodulin-binding motif

KeywordsUniProt

• Actin-binding
• ATP-binding
• Cell projection
• Cytoplasm
• Cytoskeleton
• Hearing
• Kinase
• Motor protein
• Myosin
• Nucleotide-binding
• Repeat
• Sensory transduction
• Serine/threonine-protein kinase
• Transferase
• Vision

InteractionsUniProt · HPA

Protein binding partners of MYO3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ESPNL
• ESPN