Seroatlas · Human Serome Atlas

ARL4C

ADP-ribosylation factor-like protein 4C

Also known as: ARL4C_HUMAN, ARL7, LAK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56559
Gene: ARL4C
Ensembl: ENSG00000188042
Chromosome: 2
Canonical length: 192 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>P56559|ARL4C
     1  MGNISSNISA FQSLHIVMLG LDSAGKTTVL YRLKFNEFVN TVPTIGFNTE KIKLSNGTAK
    61  GISCHFWDVG GQEKLRPLWK SYSRCTDGII YVVDSVDVDR LEEAKTELHK VTKFAENQGT
   121  PLLVIANKQD LPKSLPVAEI EKQLALHELI PATTYHVQPA CAIIGEGLTE GMDKLYEMIL
   181  KRRKSLKQKK KR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL4C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

thymus: 69 nTPM
bone marrow: 61 nTPM
lymph node: 52 nTPM
spleen: 48 nTPM
choroid plexus: 40 nTPM
tonsil: 30 nTPM

Single-cell type

nk-cells: 440 nCPM
kupffer cells: 423 nCPM
t-cells: 324 nCPM
pdcs: 323 nCPM
cdc: 309 nCPM
macrophages: 272 nCPM

Immune cell

gdT-cell: 87 nTPM
MAIT T-cell: 86 nTPM
T-reg: 84 nTPM
basophil: 80 nTPM
memory CD8 T-cell: 70 nTPM
NK-cell: 61 nTPM

Brain region

choroid plexus: 96 nTPM
hypothalamus: 45 nTPM
pons: 44 nTPM
thalamus: 37 nTPM
cerebral cortex: 37 nTPM
cerebellum: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.76
gnomAD missense Z: 2.45
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL4C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CYTH2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL4C as an antibody target. Whether an autoantibody or antibody against ARL4C could matter depends on whether native ARL4C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL4C is annotated at the cell surface, where native ARL4C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARL4C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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