Seroatlas · Human Serome Atlas

RAB23

Ras-related protein Rab-23

Also known as: RAB23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULC3
Gene
RAB23
Ensembl
ENSG00000112210
Chromosome
6
Canonical length
237 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cell Junctions,Primary cilium,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q9ULC3|RAB23
     1  MLEEDMEVAI KMVVVGNGAV GKSSMIQRYC KGIFTKDYKK TIGVDFLERQ IQVNDEDVRL
    61  MLWDTAGQEE FDAITKAYYR GAQACVLVFS TTDRESFEAV SSWREKVVAE VGDIPTVLVQ
   121  NKIDLLDDSC IKNEEAEALA KRLKLRFYRT SVKEDLNVNE VFKYLAEKYL QKLKQQIAED
   181  PELTHSSSNK IGVFNTSGGS HSGQNSGTLN GGDVINLRPN KQRTKKNRNP FSSCSIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
70 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 70 nTPM
  • colon: 55 nTPM
  • seminal vesicle: 52 nTPM
  • endometrium: 49 nTPM
  • urinary bladder: 44 nTPM
  • cervix: 43 nTPM

Single-cell type

  • smooth muscle cells: 106 nCPM
  • cardiomyocytes: 43 nCPM
  • retinal pigment epithelial cells: 43 nCPM
  • decidual stromal cells: 34 nCPM
  • peritubular myoid cells: 34 nCPM
  • fibro-adipogenic progenitors: 34 nCPM

Immune cell

  • naive CD4 T-cell: 0.3 nTPM
  • eosinophil: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • hypothalamus: 27 nTPM
  • white matter: 18 nTPM
  • cerebellum: 17 nTPM
  • medulla oblongata: 14 nTPM
  • spinal cord: 14 nTPM
  • basal ganglia: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB23.

Disease | AllUniProt

Conditions RAB23 is implicated in, by any mechanism.

Disease | GeneticClinVar

38 pathogenic / likely-pathogenic of 321 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.01
gnomAD missense Z
0.32
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB23 as an antibody target. Whether an autoantibody or antibody against RAB23 could matter depends on whether native RAB23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB23 is annotated at the cell surface, where native RAB23 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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