Seroatlas · Human Serome Atlas

DLG3

Disks large homolog 3

Also known as: DLG3_HUMAN, KIAA1232, MRX90, NE-Dlg, NEDLG, PPP1R82, SAP-102, SAP102

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92796
Gene
DLG3
Ensembl
ENSG00000082458
Chromosome
X
Canonical length
817 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

817 residues, UniProt reviewed canonical sequence.

>Q92796|DLG3
     1  MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PGGGNGASAG YGGYSSQTLP
    61  SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG SGPSWWPECT CTNRDWYEQV
   121  NGSDGMFKYE EIVLERGNSG LGFSIAGGID NPHVPDDPGI FITKIIPGGA AAMDGRLGVN
   181  DCVLRVNEVD VSEVVHSRAV EALKEAGPVV RLVVRRRQPP PETIMEVNLL KGPKGLGFSI
   241  AGGIGNQHIP GDNSIYITKI IEGGAAQKDG RLQIGDRLLA VNNTNLQDVR HEEAVASLKN
   301  TSDMVYLKVA KPGSLHLNDM YAPPDYASTF TALADNHISH NSSLGYLGAV ESKVSYPAPP
   361  QVPPTRYSPI PRHMLAEEDF TREPRKIILH KGSTGLGFNI VGGEDGEGIF VSFILAGGPA
   421  DLSGELRRGD RILSVNGVNL RNATHEQAAA ALKRAGQSVT IVAQYRPEEY SRFESKIHDL
   481  REQMMNSSMS SGSGSLRTSE KRSLYVRALF DYDRTRDSCL PSQGLSFSYG DILHVINASD
   541  DEWWQARLVT PHGESEQIGV IPSKKRVEKK ERARLKTVKF HARTGMIESN RDFPGLSDDY
   601  YGAKNLKGQE DAILSYEPVT RQEIHYARPV IILGPMKDRV NDDLISEFPH KFGSCVPHTT
   661  RPRRDNEVDG QDYHFVVSRE QMEKDIQDNK FIEAGQFNDN LYGTSIQSVR AVAERGKHCI
   721  LDVSGNAIKR LQQAQLYPIA IFIKPKSIEA LMEMNRRQTY EQANKIYDKA MKLEQEFGEY
   781  FTAIVQGDSL EEIYNKIKQI IEDQSGHYIW VPSPEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 34 nTPM
  • pancreas: 34 nTPM
  • epididymis: 24 nTPM
  • salivary gland: 22 nTPM
  • cerebral cortex: 21 nTPM
  • esophagus: 20 nTPM

Single-cell type

  • esophageal apical cells: 89 nCPM
  • respiratory secretory cells: 72 nCPM
  • pancreatic acinar cells: 67 nCPM
  • lacrimal acinar cells: 67 nCPM
  • salivary duct cells: 65 nCPM
  • conjunctival goblet cells: 64 nCPM

Immune cell

  • memory CD8 T-cell: 0.7 nTPM
  • T-reg: 0.7 nTPM
  • gdT-cell: 0.5 nTPM
  • MAIT T-cell: 0.5 nTPM
  • NK-cell: 0.5 nTPM
  • memory CD4 T-cell: 0.4 nTPM

Brain region

  • hippocampal formation: 40 nTPM
  • cerebral cortex: 39 nTPM
  • basal ganglia: 32 nTPM
  • white matter: 25 nTPM
  • amygdala: 24 nTPM
  • hypothalamus: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DLG3.

Disease | AllUniProt

Conditions DLG3 is implicated in, by any mechanism.

  • Intellectual developmental disorder, X-linked 90 (XLID90) MIM:300850

Disease | GeneticClinVar

40 pathogenic / likely-pathogenic of 381 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.09
gnomAD pLI
1
gnomAD missense Z
2.88
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DLG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLG3 as an antibody target. Whether an autoantibody or antibody against DLG3 could matter depends on whether native DLG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLG3 is annotated at the cell surface, where native DLG3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DLG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DLG3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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