Seroatlas · Human Serome Atlas

RHOBTB1

Rho-related BTB domain-containing protein 1

Also known as: KIAA0740, RHBT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94844
Gene: RHOBTB1
Ensembl: ENSG00000072422
Chromosome: 10
Canonical length: 696 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

696 residues, UniProt reviewed canonical sequence.

>O94844|RHOBTB1
     1  MDADMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV PTVWAIDQYR
    61  VCQEVLERSR DVVDEVSVSL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLNHVKS
   121  MWYPEIKHFC PRTPVILVGC QLDLRYADLE AVNRARRPLA RPIKRGDILP PEKGREVAKE
   181  LGLPYYETSV FDQFGIKDVF DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP
   241  PVIKIPECPS MGTNEAACLL DNPLCADVLF ILQDQEHIFA HRIYLATSSS KFYDLFLMEC
   301  EESPNGSEGA CEKEKQSRDF QGRILSVDPE EEREEGPPRI PQADQWKSSN KSLVEALGLE
   361  AEGAVPETQT LTGWSKGFIG MHREMQVNPI SKRMGPMTVV RMDASVQPGP FRTLLQFLYT
   421  GQLDEKEKDL VGLAQIAEVL EMFDLRMMVE NIMNKEAFMN QEITKAFHVR KANRIKECLS
   481  KGTFSDVTFK LDDGAISAHK PLLICSCEWM AAMFGGSFVE SANSEVYLPN INKISMQAVL
   541  DYLYTKQLSP NLDLDPLELI ALANRFCLPH LVALAEQHAV QELTKAATSG VGIDGEVLSY
   601  LELAQFHNAH QLAAWCLHHI CTNYNSVCSK FRKEIKSKSA DNQEYFERHR WPPVWYLKEE
   661  DHYQRVKRER EKEDIALNKH RSRRKWCFWN SSPAVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOBTB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 135 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 135 nTPM
placenta: 35 nTPM
kidney: 29 nTPM
retina: 23 nTPM
stomach: 20 nTPM
tongue: 18 nTPM

Single-cell type

syncytiotrophoblasts: 1,919 nCPM
proximal tubule cells: 992 nCPM
retinal horizontal cells: 884 nCPM
cone photoreceptor cells: 679 nCPM
myonuclei: 527 nCPM
cytotrophoblasts: 510 nCPM

Immune cell

myeloid DC: 0.2 nTPM
NK-cell: 0.2 nTPM
total PBMC: 0.2 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

thalamus: 14 nTPM
white matter: 14 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 12 nTPM
pons: 11 nTPM
medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: 1.55
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOBTB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

COPS7B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOBTB1 as an antibody target. Whether an autoantibody or antibody against RHOBTB1 could matter depends on whether native RHOBTB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOBTB1 is annotated at the cell surface, where native RHOBTB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHOBTB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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