Seroatlas · Human Serome Atlas

AK8

Adenylate kinase 8

Also known as: C9orf98, FLJ32704, KAD8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MA6
Gene
AK8
Ensembl
ENSG00000165695
Chromosome
9
Canonical length
479 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Flagellar centriole,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Enables AMP binding activity and nucleobase-containing compound kinase activity. Predicted to be involved in nucleoside monophosphate phosphorylation. Predicted to act upstream of or within ventricular system development. Located in 9+2 motile cilium. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q96MA6|AK8
     1  MDATIAPHRI PPEMPQYGEE NHIFELMQNM LEQLLIHQPE DPIPFMIQHL HRDNDNVPRI
    61  VILGPPASGK TTIAMWLCKH LNSSLLTLEN LILNEFSYTA TEARRLYLQR KTVPSALLVQ
   121  LIQERLAEED CIKQGWILDG IPETREQALR IQTLGITPRH VIVLSAPDTV LIERNLGKRI
   181  DPQTGEIYHT TFDWPPESEI QNRLMVPEDI SELETAQKLL EYHRNIVRVI PSYPKILKVI
   241  SADQPCVDVF YQALTYVQSN HRTNAPFTPR VLLLGPVGSG KSLQAALLAQ KYRLVNVCCG
   301  QLLKEAVADR TTFGELIQPF FEKEMAVPDS LLMKVLSQRL DQQDCIQKGW VLHGVPRDLD
   361  QAHLLNRLGY NPNRVFFLNV PFDSIMERLT LRRIDPVTGE RYHLMYKPPP TMEIQARLLQ
   421  NPKDAEEQVK LKMDLFYRNS ADLEQLYGSA ITLNGDQDPY TVFEYIESGI INPLPKKIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AK8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 24 nTPM
  • epididymis: 18 nTPM
  • testis: 18 nTPM
  • choroid plexus: 9.7 nTPM
  • thyroid gland: 4.4 nTPM
  • tonsil: 4 nTPM

Single-cell type

  • respiratory ciliated cells: 324 nCPM
  • ependymal cells: 250 nCPM
  • late spermatids: 200 nCPM
  • early spermatids: 159 nCPM
  • fallopian tube ciliated cells: 125 nCPM
  • endometrial ciliated cells: 101 nCPM

Immune cell

  • memory B-cell: 6.2 nTPM
  • naive B-cell: 5 nTPM
  • NK-cell: 3.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • midbrain: 13 nTPM
  • choroid plexus: 11 nTPM
  • medulla oblongata: 8.5 nTPM
  • spinal cord: 6.4 nTPM
  • pons: 6.1 nTPM
  • hypothalamus: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
0.71
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AK8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AK8 as an antibody target. Whether an autoantibody or antibody against AK8 could matter depends on whether native AK8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AK8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AK8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AK8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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