Seroatlas · Human Serome Atlas

TRANK1

TPR and ankyrin repeat-containing protein 1

Also known as: KIAA0342, LBA1, TRNK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15050
Gene: TRANK1
Ensembl: ENSG00000168016
Chromosome: 3
Canonical length: 2925 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for TRANK1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

2925 residues, UniProt reviewed canonical sequence.

>O15050|TRANK1
     1  MWDPRAARVP PRDLAVLLCN KSNAFFSLGK WNEAFVAAKE CLQWDPTYVK GYYRAGYSLL
    61  RLHQPYEAAR MFFEGLRLVQ RSQDQAPVAD FLVGVFTTMS SDSIVLQSFL PCFDHIFTTG
   121  FPTEVWQSVI EKLAKKGLWH SFLLLSAKKD RLPRNIHVPE LSLKSLFEKY VFIGLYEKME
   181  QVPKLVQWLI SIGASVETIG PYPLHALMRL CIQARENHLF RWLMDHKPEW KGRINQKDGD
   241  GCTVLHVVAA HSPGYLVKRQ TEDVQMLLRF GADPTLLDRQ SRSVVDVLKR NKNFKAIEKI
   301  NSHLEKLATC SKDLSGFSNG DGPTSENDIF RKVLEQLVKY MNSGNRLLHK NFLKQEVVQR
   361  FLRLLSTLQE IPPDLVCDIN QDCATTVFKF LLEKQRWPEV LLLLTRKVSG EPPLGDCLIK
   421  DCNFSDLDIC TIIPHLSTWD QRKKQLLGCL IDSGALPDGL QESQERPVVT CLKHEDFELA
   481  FLLLTKGADP RAISLTEGDT PLHAALHIFL EIKADIGFSF LSHLLDLFWS NPTEFDYLNP
   541  NVQDSNGNTL MHILFQKGML KRVKKLLDLL VKFDINFNLK NKEGKDARHR IKKNDSLLLA
   601  WNKALMENRR RSRQDSAAHL GKLSKSTAPG HTSQLKSQGS FKSVPCGATA RTLPEGSAVP
   661  DSWETLPGTQ VTRKEPGALR PCSLRDCLMQ DITVLIQQVE VDPSFPEDCL QSSEPLEAGA
   721  GKEGKKDDKP TLGAGAPDCS EVGEGHAQVG LGALQLVPDD NRGKEGNDDQ DDWSTQEIEA
   781  CLQDFDNMTW EIECTSEMLK KLSSKVMTKV IKKKIILAIQ QLGNGEWTQG LQKRLKHLKG
   841  SIQLFEAKLD KGARMLWELA IDFSPRCSEN PEKIIATEQN TCAMEKSGRI YTEIIRIWDI
   901  VLDHCKLADS IKAICNAYNR GLSCVLRKKL KGINKGQVSA NMKIQKRIPR CYVEDTEAEK
   961  GREHVNPEYF PPASAVETEY NIMKFHSFST NMAFNILNDT TATVEYPFRV GELEYAVIDL
  1021  NPRPLEPIIL IGRSGTGKTT CCLYRLWKKF HVYWEKAEQA GSPLLAKQVW LKRRLEVEPG
  1081  KESPGGEEEE EEEDEEEEDS IEVETVESID EQEYEACAGG AGVEPAGDGQ AAEVCAPEHP
  1141  HQLEHLHQIF VTKNHVLCQE VQRNFIELSK STKATSHYKP LDPNIHKLQD LRDENFPLFV
  1201  TSKQLLLLLD ASLPKPFFLR NEDGSLKRTI IGWSAQEEST IPSWQEDEEE AEVDGDYSEE
  1261  DKAVEMRTGD SDPRVYVTFE VFKNEIWPKM TKGRTAYNPA LIWKEIKSFL KGSFEALSCP
  1321  HGRLTEEVYK KLGRKRCPNF KEDRSEIYSL FSLYQQIRSQ KGYFDEEDVL YNISRRLSKL
  1381  RVLPWSIHEL YGDEIQDFTQ AELALLMKCI NDPNSMFLTG DTAQSIMKGV AFRFSDLRSL
  1441  FHYASRNTID KQCAVRKPKK IHQLYQNYRS HSGILNLASG VVDLLQFYFP ESFDRLPRDS
  1501  GLFDGPKPTV LESCSVSDLA ILLRGNKRKT QPIEFGAHQV ILVANETAKE KIPEELGLAL
  1561  VLTIYEAKGL EFDDVLLYNF FTDSEAYKEW KIISSFTPTS TDSREENRPL VEVPLDKPGS
  1621  SQGRSLMVNP EMYKLLNGEL KQLYTAITRA RVNLWIFDEN REKRAPAFKY FIRRDFVQVV
  1681  KTDENKDFDD SMFVKTSTPA EWIAQGDYYA KHQCWKVAAK CYQKGGAFEK EKLALAHDTA
  1741  LSMKSKKVSP KEKQLEYLEL AKTYLECKEP TLSLKCLSYA KEFQLSAQLC ERLGKIRDAA
  1801  YFYKRSQCYK DAFRCFEQIQ EFDLALKMYC QEELFEEAAI AVEKYEEMLK TKTLPISKLS
  1861  YSASQFYLEA AAKYLSANKM KEMMAVLSKL DIEDQLVFLK SRKRLAEAAD LLNREGRREE
  1921  AALLMKQHGC LLEAARLTAD KDFQASCLLG AARLNVARDS DIEHTKDILR EALDICYQTG
  1981  QLSGIAEAHF LQGVILRDFQ KLRDAFFKFD TLNHSAGVVE ALYEAASQCE AEPEKILGLA
  2041  PGGLEILLSL VRALKRVTNN AEKEMVKSCF EFFGISQVDA KYCQIAQNDP GPILRIIFDL
  2101  DLNLREKKTK DHFLIMTDQV KLALNKHLLG RLCQITRSLL GKTYRGVCMR FIVGLKCEDE
  2161  NCEHFHRPLR RCEAKCLVQS KMNLVAINGL LLEAKKVFPK ILAEELKEID YILSTDMYGL
  2221  CKSILDVLFP KHFHQRVLSE NPMACKEILK PNYKSFRFYR FALKEYIHFL FENESARNRR
  2281  ESTDLWLSAM QAFLLSSNYP EEFEKLLHQE EDNYNRELKA LESEKDERGR GRGSRIKGIE
  2341  GKFGMLAPNR DDENMDKTHL CFIRLLENCI DQFYVYRNPE DYKRLFFRFM NVLIKRCKEP
  2401  LIPSIGNTVA LLEFQFIHCG VVLARLWKNV ILCLPKSYIA LLHYWEFLFS KKDKELGDVF
  2461  SIIQEYKPKD VTRAIQDFRF HLSYLAKVLC GYENVNFNVL LDAFSEIDYV VSGEAERTLV
  2521  LCLVMLVNAE EILQPYCKPL LYRHFREIES RLQLMSMDCP GQVPERLLKV VKRVLVAVNV
  2581  KSVAEALQDL LFERDEEYLM DCDWRWDPVH TKGSIVRGLY YEEVRLNRLL CLDPVDYFAE
  2641  PECEFGQDEM DELALEDRDH VLATILSQKQ RKASIQRKLR RACLVVSLCI SWRRRVGTQM
  2701  ERVREEAREP RAGNFKKADV DRTQCDLCGV KFTRGPENYF SPSKAFEGAA SEVAVLSRAE
  2761  LEREECQERN SESYEQHIHL EHHQRQQVAY QKYSEFFHEK VDPAIDEGKL VVQDIEQSVW
  2821  IHSHVGSKEH SHMLQKVQEH IKRVSDMVED LYRRKAWAGA EEAMTRLVNI LILSVRDARD
  2881  WLMKTETRLK KEGIVQEDDY ENEVEDFGEL RPRRRSRKCG KQRKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRANK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 20 nTPM
tonsil: 20 nTPM
lymph node: 17 nTPM
cerebellum: 17 nTPM
thymus: 16 nTPM
small intestine: 16 nTPM

Single-cell type

granulosa cells: 135 nCPM
microglia: 130 nCPM
adrenal medulla cells: 128 nCPM
retinal ganglion cells: 128 nCPM
goblet cells: 127 nCPM
neutrophils: 119 nCPM

Immune cell

neutrophil: 116 nTPM
naive B-cell: 18 nTPM
memory CD8 T-cell: 15 nTPM
gdT-cell: 15 nTPM
memory CD4 T-cell: 12 nTPM
T-reg: 12 nTPM

Brain region

cerebral cortex: 30 nTPM
cerebellum: 26 nTPM
hypothalamus: 22 nTPM
basal ganglia: 20 nTPM
spinal cord: 20 nTPM
pons: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: 2.08
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Ankyrin repeat
Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
P-loop containing nucleoside triphosphate hydrolase
Ankyrin repeat-containing domain superfamily
TPR and ankyrin repeat-containing protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRANK1 as an antibody target. Whether an autoantibody or antibody against TRANK1 could matter depends on whether native TRANK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRANK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRANK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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