RAB7B
Ras-related protein Rab-7b
Also known as: MGC16212, MGC9726, RAB7B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96AH8
- Gene
- RAB7B
- Ensembl
- ENSG00000276600
- Chromosome
- 1
- Canonical length
- 199 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable GTP binding activity and GTPase activity. Involved in late endosome to Golgi transport; positive regulation of megakaryocyte differentiation; and regulation of gene expression. Located in cytoplasmic vesicle; lysosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
199 residues, UniProt reviewed canonical sequence.
>Q96AH8|RAB7B
1 MNPRKKVDLK LIIVGAIGVG KTSLLHQYVH KTFYEEYQTT LGASILSKII ILGDTTLKLQ
61 IWDTGGQERF RSMVSTFYKG SDGCILAFDV TDLESFEALD IWRGDVLAKI VPMEQSYPMV
121 LLGNKIDLAD RKVPQEVAQG WCREKDIPYF EVSAKNDINV VQAFEMLASR ALSRYQSILE
181 NHLTESIKLS PDQSRSRCCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 49 nTPM
Expression across tissuesHPA
Tissue
- skin: 49 nTPM
- esophagus: 20 nTPM
- vagina: 15 nTPM
- cervix: 15 nTPM
- gallbladder: 14 nTPM
- breast: 10 nTPM
Single-cell type
- cdc: 205 nCPM
- epicardial cells: 139 nCPM
- esophageal basal cells: 54 nCPM
- cytotrophoblasts: 48 nCPM
- macrophages: 42 nCPM
- fibro-adipogenic progenitors: 40 nCPM
Immune cell
- myeloid DC: 5.1 nTPM
- plasmacytoid DC: 0.9 nTPM
- classical monocyte: 0.6 nTPM
- total PBMC: 0.3 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- white matter: 14 nTPM
- thalamus: 12 nTPM
- medulla oblongata: 8.3 nTPM
- spinal cord: 7.6 nTPM
- midbrain: 6.5 nTPM
- cerebellum: 6.4 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about RAB7B.
Disease | ImmuneIEDB
Conditions an epitope on RAB7B was assayed in.
- endometrial cancer T cell
- pancreatic cancer T cell
OntologyGO
Biological processes
- cellular response to type II interferon
- endosome to lysosome transport
- late endosome to Golgi transport
- negative regulation of toll-like receptor 4 signaling pathway
- negative regulation of toll-like receptor 9 signaling pathway
- phagosome-lysosome fusion
- positive regulation of interleukin-6 production
- positive regulation of megakaryocyte differentiation
- positive regulation of NF-kappaB transcription factor activity
- protein transport
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB7B as an antibody target. Whether an autoantibody or antibody against RAB7B could matter depends on whether native RAB7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB7B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RAB7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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