RASD1

Protein identityUniProt · HPA

UniProt accession

Q9Y272

Gene

RASD1

Ensembl

ENSG00000108551

Chromosome

17

Canonical length

281 aa

Protein class

Human disease related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>Q9Y272|RASD1
     1  MKLAAMIKKM CPSDSELSIP AKNCYRMVIL GSSKVGKTAI VSRFLTGRFE DAYTPTIEDF
    61  HRKFYSIRGE VYQLDILDTS GNHPFPAMRR LSILTGDVFI LVFSLDNRDS FEEVQRLRQQ
   121  ILDTKSCLKN KTKENVDVPL VICGNKGDRD FYREVDQREI EQLVGDDPQR CAYFEISAKK
   181  NSSLDQMFRA LFAMAKLPSE MSPDLHRKVS VQYCDVLHKK ALRNKKLLRA GSGGGGGDPG
   241  DAFGIVAPFA RRPSVHSDLM YIREKASAGS QAKDKERCVI S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

352 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.18

gnomAD pLI

0.04

gnomAD missense Z

0.37

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G protein-coupled receptor signaling pathway
• negative regulation of DNA-templated transcription
• nitric oxide mediated signal transduction
• signal transduction

Molecular functions

• G-protein beta-subunit binding
• GTP binding
• GTPase activity

Cellular components

• cytoplasm
• nucleus
• perinuclear region of cytoplasm
• plasma membrane
• sarcoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

• Small GTPase
• Small GTP-binding domain
• P-loop containing nucleoside triphosphate hydrolase
• Small GTPase RasD
• Ras family

KeywordsUniProt

• Cell membrane
• Cytoplasm
• GTP-binding
• Lipoprotein
• Membrane
• Methylation
• Nucleotide-binding
• Nucleus
• Prenylation
• S-nitrosylation

InteractionsUniProt · HPA

Protein binding partners of RASD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NOS1AP