Seroatlas · Human Serome Atlas

RASEF

Ras and EF-hand domain-containing protein

Also known as: FLJ31614, RAB45, RASEF_HUMAN, TSG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ41
Gene: RASEF
Ensembl: ENSG00000165105
Chromosome: 9
Canonical length: 740 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

740 residues, UniProt reviewed canonical sequence.

>Q8IZ41|RASEF
     1  MEADGDGEEL ARLRSVFAAC DANRSGRLER EEFRALCTEL RVRPADAEAV FQRLDADRDG
    61  AITFQEFARG FLGSLRGGRR RDWGPLDPAP AVSEAGPETH DSEEDEGDED AAAALATSCG
   121  PASPGRAWQD FQARLGDEAK FIPREEQVST LYQNINLVEP RLIQPYEHVI KNFIREIRLQ
   181  STEMENLAIA VKRAQDKAAM QLSELEEEMD QRIQAAEHKT RKDEKRKAEE ALSDLRRQYE
   241  TEVGDLQVTI KKLRKLEEQS KRVSQKEDVA ALKKQIYDLS MENQKVKKDL LEAQTNIAFL
   301  QSELDALKSD YADQSLNTER DLEIIRAYTE DRNSLERQIE ILQTANRKLH DSNDGLRSAL
   361  ENSYSKFNRS LHINNISPGN TISRSSPKFI GHSPQPLGYD RSSRSSYVDE DCDSLALCDP
   421  LQRTNCEVDS LPESCFDSGL STLRDPNEYD SEVEYKHQRG FQRSHGVQES FGGDASDTDV
   481  PDIRDEETFG LEDVASVLDW KPQGSVSEGS IVSSSRKPIS ALSPQTDLVD DNAKSFSSQK
   541  AYKIVLAGDA AVGKSSFLMR LCKNEFRENI SATLGVDFQM KTLIVDGERT VLQLWDTAGQ
   601  ERFRSIAKSY FRKADGVLLL YDVTCEKSFL NIREWVDMIE DAAHETVPIM LVGNKADIRD
   661  TAATEGQKCV PGHFGEKLAM TYGALFCETS AKDGSNIVEA VLHLAREVKK RTDKDDSRSI
   721  TNLTGTNSKK SPQMKNCCNG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASEF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

stomach: 38 nTPM
thyroid gland: 24 nTPM
pancreas: 21 nTPM
breast: 16 nTPM
colon: 14 nTPM
rectum: 14 nTPM

Single-cell type

foveolar cells: 1,190 nCPM
prostatic glandular cells: 549 nCPM
endometrial glandular cells: 540 nCPM
urothelial cells: 457 nCPM
pancreatic acinar cells: 441 nCPM
alveolar cells type 2: 424 nCPM

Immune cell

neutrophil: 7 nTPM
naive B-cell: 3.7 nTPM
basophil: 3.2 nTPM
memory B-cell: 2.8 nTPM
gdT-cell: 2.7 nTPM
naive CD4 T-cell: 2.7 nTPM

Brain region

choroid plexus: 86 nTPM
white matter: 82 nTPM
cerebellum: 81 nTPM
cerebral cortex: 80 nTPM
basal ganglia: 73 nTPM
amygdala: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASEF as an antibody target. Whether an autoantibody or antibody against RASEF could matter depends on whether native RASEF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASEF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASEF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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