GNAT3

Protein identityUniProt · HPA

UniProt accession

A8MTJ3

Gene

GNAT3

Ensembl

ENSG00000214415

Chromosome

7

Canonical length

354 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles,Basal body

OverviewNCBI Gene

Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>A8MTJ3|GNAT3
     1  MGSGISSESK ESAKRSKELE KKLQEDAERD ARTVKLLLLG AGESGKSTIV KQMKIIHKNG
    61  YSEQECMEFK AVIYSNTLQS ILAIVKAMTT LGIDYVNPRS AEDQRQLYAM ANTLEDGGMT
   121  PQLAEVIKRL WRDPGIQACF ERASEYQLND SAAYYLNDLD RITASGYVPN EQDVLHSRVK
   181  TTGIIETQFS FKDLHFRMFD VGGQRSERKK WIHCFEGVTC IIFCAALSAY DMVLVEDEEV
   241  NRMHESLHLF NSICNHKYFS TTSIVLFLNK KDIFQEKVTK VHLSICFPEY TGPNTFEDAG
   301  NYIKNQFLDL NLKKEDKEIY SHMTCATDTQ NVKFVFDAVT DIIIKENLKD CGLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

1.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.03

gnomAD pLI

0

gnomAD missense Z

0.26

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-modulating G protein-coupled receptor signaling pathway
• detection of light stimulus involved in visual perception
• phototransduction, visible light
• response to nicotine
• sensory perception of bitter taste
• sensory perception of sweet taste
• sensory perception of umami taste

Molecular functions

• G protein-coupled receptor binding
• G-protein beta/gamma-subunit complex binding
• GTP binding
• GTPase activity
• metal ion binding

Cellular components

• acrosomal vesicle
• apical plasma membrane
• axoneme
• cytoplasm
• heterotrimeric G-protein complex
• plasma membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Guanine nucleotide binding protein, alpha subunit
• G-protein alpha subunit, group I
• G protein alpha subunit, helical insertion
• P-loop containing nucleoside triphosphate hydrolase
• G-protein alpha subunit

KeywordsUniProt

• Cytoplasm
• GTP-binding
• Lipoprotein
• Magnesium
• Metal-binding
• Myristate
• Nucleotide-binding
• Transducer

InteractionsUniProt · HPA

Protein binding partners of GNAT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TAS2R14
• RHO