ARL8B
ADP-ribosylation factor-like protein 8B
Also known as: ARL10C, ARL8B_HUMAN, FLJ10702, Gie1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NVJ2
- Gene
- ARL8B
- Ensembl
- ENSG00000134108
- Chromosome
- 3
- Canonical length
- 186 aa
- Protein class
- Enzymes, Predicted intracellular proteins
OverviewNCBI Gene
Enables G protein activity; guanyl ribonucleotide binding activity; and tubulin binding activity. Involved in several processes, including antigen processing and presentation following phagocytosis; cytosolic transport; and vesicle fusion. Located in cytolytic granule membrane; midbody; and spindle midzone. Is active in early endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
186 residues, UniProt reviewed canonical sequence.
>Q9NVJ2|ARL8B
1 MLALISRLLD WFRSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI PTVGFNMRKV
61 TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMIDAAD REKIEASRNE LHNLLDKPQL
121 QGIPVLVLGN KRDLPNALDE KQLIEKMNLS AIQDREICCY SISCKEKDNI DITLQWLIQH
181 SKSRRSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARL8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 99 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 99 nTPM
- cerebral cortex: 75 nTPM
- esophagus: 71 nTPM
- skin: 64 nTPM
- thyroid gland: 58 nTPM
- spinal cord: 58 nTPM
Single-cell type
- esophageal apical cells: 607 nCPM
- monocytes: 503 nCPM
- endometrial glandular cells: 362 nCPM
- syncytiotrophoblasts: 326 nCPM
- ocular epithelial cells: 320 nCPM
- monocyte progenitors: 293 nCPM
Immune cell
- basophil: 43 nTPM
- classical monocyte: 38 nTPM
- intermediate monocyte: 33 nTPM
- myeloid DC: 32 nTPM
- total PBMC: 28 nTPM
- non-classical monocyte: 28 nTPM
Brain region
- cerebral cortex: 96 nTPM
- white matter: 90 nTPM
- spinal cord: 87 nTPM
- pons: 86 nTPM
- thalamus: 85 nTPM
- hypothalamus: 84 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.65
- gnomAD pLI
- 0.13
- gnomAD missense Z
- 2.5
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- anterograde axonal transport
- autophagosome-lysosome fusion
- calcium ion regulated lysosome exocytosis
- cell division
- chromosome segregation
- early endosome to Golgi transport
- endosome to lysosome transport of low-density lipoprotein particle
- late endosome to lysosome transport
- lysosome localization
- natural killer cell mediated cytotoxicity
- phagosome-lysosome fusion
- plasma membrane repair
- protein localization to early endosome
- protein transport
- antigen processing and presentation following phagocytosis
- antigen processing and presentation of polysaccharide antigen via MHC class II
- viral exocytosis
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ARL8B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARL8B as an antibody target. Whether an autoantibody or antibody against ARL8B could matter depends on whether native ARL8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARL8B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ARL8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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