Seroatlas · Human Serome Atlas

GBP6

Guanylate-binding protein 6

Also known as: DKFZp686G0786, GBP6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZN66
Gene: GBP6
Ensembl: ENSG00000183347
Chromosome: 1
Canonical length: 633 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

633 residues, UniProt reviewed canonical sequence.

>Q6ZN66|GBP6
     1  MESGPKMLAP VCLVENNNEQ LLVNQQAIQI LEKISQPVVV VAIVGLYRTG KSYLMNHLAG
    61  QNHGFPLGST VQSETKGIWM WCVPHPSKPN HTLVLLDTEG LGDVEKGDPK NDSWIFALAV
   121  LLCSTFVYNS MSTINHQALE QLHYVTELTE LIKAKSSPRP DGVEDSTEFV SFFPDFLWTV
   181  RDFTLELKLN GHPITEDEYL ENALKLIQGN NPRVQTSNFP RECIRRFFPK RKCFVFDRPT
   241  NDKDLLANIE KVSEKQLDPK FQEQTNIFCS YIFTHARTKT LREGITVTGN RLGTLAVTYV
   301  EAINSGAVPC LENAVITLAQ RENSAAVQRA ADYYSQQMAQ RVKLPTDTLQ ELLDMHAACE
   361  REAIAIFMEH SFKDENQEFQ KKFMETTMNK KGDFLLQNEE SSVQYCQAKL NELSKGLMES
   421  ISAGSFSVPG GHKLYMETKE RIEQDYWQVP RKGVKAKEVF QRFLESQMVI EESILQSDKA
   481  LTDREKAVAV DRAKKEAAEK EQELLKQKLQ EQQQQMEAQD KSRKENIAQL KEKLQMEREH
   541  LLREQIMMLE HTQKVQNDWL HEGFKKKYEE MNAEISQFKR MIDTTKNDDT PWIARTLDNL
   601  ADELTAILSA PAKLIGHGVK GVSSLFKKHK LPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GBP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 276 nTPM

Expression across tissuesHPA

Tissue

esophagus: 276 nTPM
tonsil: 52 nTPM
salivary gland: 43 nTPM
vagina: 25 nTPM
cervix: 23 nTPM
thymus: 1 nTPM

Single-cell type

esophageal suprabasal cells: 1,775 nCPM
esophageal apical cells: 1,159 nCPM
suprabasal keratinocytes: 977 nCPM
esophageal basal cells: 475 nCPM
basal keratinocytes: 188 nCPM
respiratory ciliated cells: 27 nCPM

Immune cell

neutrophil: 0.6 nTPM
T-reg: 0.5 nTPM
basophil: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

pons: 1.8 nTPM
medulla oblongata: 1.5 nTPM
cerebellum: 1.4 nTPM
cerebral cortex: 1.4 nTPM
spinal cord: 1.4 nTPM
thalamus: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GBP6 as an antibody target. Whether an autoantibody or antibody against GBP6 could matter depends on whether native GBP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GBP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GBP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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