Seroatlas · Human Serome Atlas

ELP6

Elongator complex protein 6

Also known as: C3orf75, ELP6_HUMAN, FLJ20211, TMEM103

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0PNE2
Gene: ELP6
Ensembl: ENSG00000163832
Chromosome: 3
Canonical length: 266 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of cell migration. Predicted to act upstream of or within several processes, including autophagosome maturation; gene expression; and homeostasis of number of retina cells. Located in cytosol and nucleus. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>Q0PNE2|ELP6
     1  MFVELNNLLN TTPDRAEQGK LTLLCDAKTD GSFLVHHFLS FYLKANCKVC FVALIQSFSH
    61  YSIVGQKLGV SLTMARERGQ LVFLEGLKSA VDVVFQAQKE PHPLQFLREA NAGNLKPLFE
   121  FVREALKPVD SGEARWTYPV LLVDDLSVLL SLGMGAVAVL DFIHYCRATV CWELKGNMVV
   181  LVHDSGDAED EENDILLNGL SHQSHLILRA EGLATGFCRD VHGQLRILWR RPSQPAVHRD
   241  QSFTYQYKIQ DKSVSFFAKG MSPAVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 33 nTPM
adrenal gland: 29 nTPM
tongue: 27 nTPM
choroid plexus: 27 nTPM
ovary: 24 nTPM
liver: 23 nTPM

Single-cell type

megakaryocytes: 68 nCPM
megakaryocyte progenitors: 61 nCPM
cytotrophoblasts: 58 nCPM
retinal horizontal cells: 56 nCPM
respiratory ionocytes: 53 nCPM
epididymal principal cells: 53 nCPM

Immune cell

T-reg: 39 nTPM
naive B-cell: 35 nTPM
NK-cell: 35 nTPM
plasmacytoid DC: 34 nTPM
memory B-cell: 34 nTPM
memory CD8 T-cell: 33 nTPM

Brain region

choroid plexus: 29 nTPM
cerebellum: 27 nTPM
white matter: 27 nTPM
medulla oblongata: 26 nTPM
thalamus: 26 nTPM
cerebral cortex: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.81
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

P-loop containing nucleoside triphosphate hydrolase
Elongator complex protein 6
Elongation complex protein 6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ELP5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELP6 as an antibody target. Whether an autoantibody or antibody against ELP6 could matter depends on whether native ELP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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