Seroatlas · Human Serome Atlas

RAB27A

Ras-related protein Rab-27A

Also known as: GS2, HsT18676, RAB27, RAM, RB27A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51159
Gene
RAB27A
Ensembl
ENSG00000069974
Chromosome
15
Canonical length
221 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Mid piece,Principal piece

OverviewNCBI Gene

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>P51159|RAB27A
     1  MSDGDYDYLI KFLALGDSGV GKTSVLYQYT DGKFNSKFIT TVGIDFREKR VVYRASGPDG
    61  ATGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD LTNEQSFLNV RNWISQLQMH
   121  AYCENPDIVL CGNKSDLEDQ RVVKEEEAIA LAEKYGIPYF ETSAANGTNI SQAIEMLLDL
   181  IMKRMERCVD KSWIPEGVVR SNGHASTDQL SEEKEKGACG C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB27A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
114 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 114 nTPM
  • bone marrow: 95 nTPM
  • rectum: 63 nTPM
  • prostate: 59 nTPM
  • colon: 51 nTPM
  • lymph node: 44 nTPM

Single-cell type

  • neutrophil progenitors: 1,541 nCPM
  • neutrophils: 1,394 nCPM
  • alveolar cells type 2: 417 nCPM
  • goblet cells: 376 nCPM
  • foveolar cells: 313 nCPM
  • gonadotrophs: 294 nCPM

Immune cell

  • basophil: 262 nTPM
  • neutrophil: 115 nTPM
  • eosinophil: 100 nTPM
  • classical monocyte: 72 nTPM
  • memory CD8 T-cell: 62 nTPM
  • gdT-cell: 59 nTPM

Brain region

  • hypothalamus: 9.8 nTPM
  • thalamus: 9.5 nTPM
  • pons: 9.1 nTPM
  • medulla oblongata: 8.9 nTPM
  • white matter: 8.9 nTPM
  • choroid plexus: 8.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RAB27A.

Disease | AllUniProt

Conditions RAB27A is implicated in, by any mechanism.

Disease | GeneticClinVar

60 pathogenic / likely-pathogenic of 342 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Griscelli syndrome type 2
  • Autoinflammatory syndrome
  • RAB27A-related disorder
  • See cases
  • Multisystem inflammatory syndrome in children

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0
gnomAD missense Z
-0.51
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB27A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB27A as an antibody target. Whether an autoantibody or antibody against RAB27A could matter depends on whether native RAB27A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB27A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB27A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB27A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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