Seroatlas · Human Serome Atlas

RHOH

Rho-related GTP-binding protein RhoH

Also known as: ARHH, RHOH_HUMAN, TTF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15669
Gene
RHOH
Ensembl
ENSG00000168421
Chromosome
4
Canonical length
191 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>Q15669|RHOH
     1  MLSSIKCVLV GDSAVGKTSL LVRFTSETFP EAYKPTVYEN TGVDVFMDGI QISLGLWDTA
    61  GNDAFRSIRP LSYQQADVVL MCYSVANHNS FLNLKNKWIG EIRSNLPCTP VLVVATQTDQ
   121  REMGPHRASC VNAMEGKKLA QDVRAKGYLE CSALSNRGVQ QVFECAVRTA VNQARRRNRR
   181  RLFSINECKI F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
99 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 99 nTPM
  • lymph node: 92 nTPM
  • tonsil: 86 nTPM
  • bone marrow: 70 nTPM
  • appendix: 39 nTPM
  • spleen: 34 nTPM

Single-cell type

  • mast cells: 1,000 nCPM
  • b-cells: 771 nCPM
  • plasma cells: 723 nCPM
  • t-cells: 643 nCPM
  • thymocytes: 379 nCPM
  • nk-cells: 359 nCPM

Immune cell

  • naive CD4 T-cell: 308 nTPM
  • T-reg: 296 nTPM
  • naive CD8 T-cell: 253 nTPM
  • naive B-cell: 239 nTPM
  • basophil: 231 nTPM
  • memory CD4 T-cell: 201 nTPM

Brain region

  • midbrain: 4.3 nTPM
  • white matter: 3.9 nTPM
  • medulla oblongata: 3.8 nTPM
  • spinal cord: 3.5 nTPM
  • pons: 3.4 nTPM
  • hypothalamus: 3.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RHOH.

Disease | AllUniProt

Conditions RHOH is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0.15
gnomAD missense Z
1.67
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOH as an antibody target. Whether an autoantibody or antibody against RHOH could matter depends on whether native RHOH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOH is annotated at the cell surface, where native RHOH is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHOH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RHOH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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