Seroatlas · Human Serome Atlas

RHOB

Rho-related GTP-binding protein RhoB

Also known as: ARH6, ARHB, MST081, RHOB_HUMAN, RHOH6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62745
Gene: RHOB
Ensembl: ENSG00000143878
Chromosome: 2
Canonical length: 196 aa
Protein class: Cancer-related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>P62745|RHOB
     1  MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT
    61  AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD
   121  LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ
   181  KRYGSQNGCI NCCKVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 1,648 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 1,648 nTPM
colon: 615 nTPM
liver: 601 nTPM
fallopian tube: 588 nTPM
adipose tissue: 562 nTPM
adrenal gland: 509 nTPM

Single-cell type

hepatocytes: 1,697 nCPM
vascular smooth muscle cells: 1,162 nCPM
epididymal principal cells: 899 nCPM
epididymal efferent duct absorptive cells: 773 nCPM
smooth muscle cells: 744 nCPM
cholangiocytes: 704 nCPM

Immune cell

neutrophil: 22 nTPM
eosinophil: 18 nTPM
non-classical monocyte: 13 nTPM
intermediate monocyte: 11 nTPM
basophil: 5.6 nTPM
classical monocyte: 2.5 nTPM

Brain region

medulla oblongata: 667 nTPM
white matter: 654 nTPM
spinal cord: 620 nTPM
basal ganglia: 608 nTPM
midbrain: 578 nTPM
cerebellum: 568 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0.12
gnomAD missense Z: 2.51
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHOB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHOB as an antibody target. Whether an autoantibody or antibody against RHOB could matter depends on whether native RHOB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHOB is annotated at the cell surface, where native RHOB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHOB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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