Seroatlas · Human Serome Atlas

CDC42

Cell division control protein 42 homolog

Also known as: CDC42_HUMAN, CDC42Hs, G25K

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60953
Gene
CDC42
Ensembl
ENSG00000070831
Chromosome
1
Canonical length
191 aa
Protein class
Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Microtubules,Cytokinetic bridge

OverviewNCBI Gene

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>P60953|CDC42
     1  MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG
    61  QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR
   121  DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP
   181  EPKKSRRCVL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
237 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 237 nTPM
  • esophagus: 142 nTPM
  • spinal cord: 135 nTPM
  • skin: 127 nTPM
  • hypothalamus: 119 nTPM
  • adipose tissue: 114 nTPM

Single-cell type

  • papillary tip epithelial cells: 153 nCPM
  • other brain neurons: 130 nCPM
  • microglia: 123 nCPM
  • renal collecting duct principal cells: 107 nCPM
  • oligodendrocytes: 97 nCPM
  • renal collecting duct intercalated cells: 91 nCPM

Immune cell

  • neutrophil: 141 nTPM
  • non-classical monocyte: 138 nTPM
  • basophil: 114 nTPM
  • intermediate monocyte: 111 nTPM
  • eosinophil: 96 nTPM
  • total PBMC: 73 nTPM

Brain region

  • hypothalamus: 128 nTPM
  • white matter: 125 nTPM
  • pons: 123 nTPM
  • medulla oblongata: 117 nTPM
  • choroid plexus: 112 nTPM
  • midbrain: 111 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDC42.

Disease | AllUniProt

Conditions CDC42 is implicated in, by any mechanism.

Disease | GeneticClinVar

22 pathogenic / likely-pathogenic of 155 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.79
gnomAD missense Z
3.04
DepMap mean gene effect
-1.03
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC42 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC42 as an antibody target. Whether an autoantibody or antibody against CDC42 could matter depends on whether native CDC42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC42 is annotated at the cell surface, where native CDC42 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDC42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC42. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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