Seroatlas · Human Serome Atlas

ARL11

ADP-ribosylation factor-like protein 11

Also known as: ARL11_HUMAN, ARLTS1, FLJ33930

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969Q4
Gene: ARL11
Ensembl: ENSG00000152213
Chromosome: 13
Canonical length: 196 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Intermediate filaments,Cytosol

OverviewNCBI Gene

This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>Q969Q4|ARL11
     1  MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP LKAPGHVSLT
    61  LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA AELTEVLNDP NMAGVPFLVL
   121  ANKQEAPDAL PLLKIRNRLS LERFQDHCWE LRGCSALTGE GLPEALQSLW SLLKSRSCMC
   181  LQARAHGAER GDSKRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

lymph node: 6.4 nTPM
spleen: 4.5 nTPM
appendix: 3.6 nTPM
tonsil: 3.6 nTPM
thymus: 3.4 nTPM
bone marrow: 3.3 nTPM

Single-cell type

neutrophils: 124 nCPM
hofbauer cells: 45 nCPM
kupffer cells: 45 nCPM
neutrophil progenitors: 40 nCPM
microglia: 27 nCPM
monocyte progenitors: 26 nCPM

Immune cell

neutrophil: 38 nTPM
basophil: 22 nTPM
intermediate monocyte: 18 nTPM
eosinophil: 16 nTPM
classical monocyte: 15 nTPM
non-classical monocyte: 13 nTPM

Brain region

white matter: 3.4 nTPM
thalamus: 3.3 nTPM
medulla oblongata: 3.1 nTPM
cerebral cortex: 2.5 nTPM
choroid plexus: 2.5 nTPM
pons: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARL11.

Disease | AllUniProt

Conditions ARL11 is implicated in, by any mechanism.

Leukemia, chronic lymphocytic (CLL) MIM:151400

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.01
gnomAD missense Z: -0.09
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL11 as an antibody target. Whether an autoantibody or antibody against ARL11 could matter depends on whether native ARL11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL11 is annotated at the cell surface, where native ARL11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARL11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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