Seroatlas · Human Serome Atlas

REM2

GTP-binding protein REM 2

Also known as: FLJ38964, REM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYK8
Gene: REM2
Ensembl: ENSG00000139890
Chromosome: 14
Canonical length: 340 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q8IYK8|REM2
     1  MHTDLDTDMD MDTETTALCP SGSRRASPPG TPTPEADATL LKKSEKLLAE LDRSGLPSAP
    61  GAPRRRGSMP VPYKHQLRRA QAVDELDWPP QASSSGSSDS LGSGEAAPAQ KDGIFKVMLV
   121  GESGVGKSTL AGTFGGLQGD SAHEPENPED TYERRIMVDK EEVTLVVYDI WEQGDAGGWL
   181  RDHCLQTGDA FLIVFSVTDR RSFSKVPETL LRLRAGRPHH DLPVILVGNK SDLARSREVS
   241  LEEGRHLAGT LSCKHIETSA ALHHNTRELF EGAVRQIRLR RGRNHAGGQR PDPGSPEGPA
   301  PPARRESLTK KAKRFLANLV PRNAKFFKQR SRSCHDLSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 9.3 nTPM
basal ganglia: 7.8 nTPM
spleen: 5.7 nTPM
pituitary gland: 5.6 nTPM
testis: 4.6 nTPM
cerebellum: 2.9 nTPM

Single-cell type

early spermatids: 38 nCPM
neutrophils: 21 nCPM
late spermatids: 14 nCPM
endometrial ciliated cells: 10 nCPM
epididymal efferent duct ciliated cells: 8.8 nCPM
pancreatic islet cells: 7.5 nCPM

Immune cell

neutrophil: 3.7 nTPM
naive B-cell: 0.9 nTPM
memory B-cell: 0.6 nTPM
naive CD8 T-cell: 0.5 nTPM
eosinophil: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM

Brain region

basal ganglia: 7 nTPM
hypothalamus: 4.6 nTPM
cerebral cortex: 4.5 nTPM
choroid plexus: 4.4 nTPM
cerebellum: 2.8 nTPM
hippocampal formation: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 1.26
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REM2 as an antibody target. Whether an autoantibody or antibody against REM2 could matter depends on whether native REM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REM2 is annotated at the cell surface, where native REM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label REM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...