Seroatlas · Human Serome Atlas

RAB5B

Ras-related protein Rab-5B

Also known as: RAB5B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61020
Gene: RAB5B
Ensembl: ENSG00000111540
Chromosome: 12
Canonical length: 215 aa
Protein class: Enzymes, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables GDP binding activity; GTP-dependent protein binding activity; and GTPase activity. Involved in antigen processing and presentation and plasma membrane to endosome transport. Located in endosome and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>P61020|RAB5B
     1  MTSRSTARPN GQPQASKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEYQE STIGAAFLTQ
    61  SVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNQETFAR AKTWVKELQR
   121  QASPSIVIAL AGNKADLANK RMVEYEEAQA YADDNSLLFM ETSAKTAMNV NDLFLAIAKK
   181  LPKSEPQNLG GAAGRSRGVD LHEQSQQNKS QCCSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 119 nTPM

Expression across tissuesHPA

Tissue

tongue: 119 nTPM
parathyroid gland: 105 nTPM
spinal cord: 104 nTPM
skeletal muscle: 94 nTPM
esophagus: 94 nTPM
seminal vesicle: 89 nTPM

Single-cell type

esophageal apical cells: 357 nCPM
neutrophil progenitors: 144 nCPM
esophageal suprabasal cells: 123 nCPM
parietal cells: 122 nCPM
syncytiotrophoblasts: 120 nCPM
foveolar cells: 113 nCPM

Immune cell

eosinophil: 33 nTPM
neutrophil: 28 nTPM
basophil: 19 nTPM
gdT-cell: 11 nTPM
non-classical monocyte: 11 nTPM
MAIT T-cell: 10 nTPM

Brain region

white matter: 139 nTPM
midbrain: 133 nTPM
cerebellum: 131 nTPM
pons: 130 nTPM
spinal cord: 128 nTPM
medulla oblongata: 127 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.03
gnomAD missense Z: 1.32
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB5B as an antibody target. Whether an autoantibody or antibody against RAB5B could matter depends on whether native RAB5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB5B is annotated at the cell surface, where native RAB5B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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