Seroatlas · Human Serome Atlas

CMPK1

UMP-CMP kinase

Also known as: CMPK, KCY_HUMAN, UMP-CMPK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P30085
Gene: CMPK1
Ensembl: ENSG00000162368
Chromosome: 1
Canonical length: 196 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>P30085|CMPK1
     1  MKPLVVFVLG GPGAGKGTQC ARIVEKYGYT HLSAGELLRD ERKNPDSQYG ELIEKYIKEG
    61  KIVPVEITIS LLKREMDQTM AANAQKNKFL IDGFPRNQDN LQGWNKTMDG KADVSFVLFF
   121  DCNNEICIER CLERGKSSGR SDDNRESLEK RIQTYLQSTK PIIDLYEEMG KVKKIDASKS
   181  VDEVFDEVVQ IFDKEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMPK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 211 nTPM

Expression across tissuesHPA

Tissue

liver: 211 nTPM
duodenum: 156 nTPM
salivary gland: 152 nTPM
small intestine: 145 nTPM
rectum: 137 nTPM
colon: 128 nTPM

Single-cell type

esophageal apical cells: 831 nCPM
platelets: 502 nCPM
esophageal suprabasal cells: 395 nCPM
parietal cells: 332 nCPM
breast lactating cells: 321 nCPM
salivary acinar cells: 311 nCPM

Immune cell

basophil: 42 nTPM
eosinophil: 23 nTPM
MAIT T-cell: 20 nTPM
T-reg: 20 nTPM
memory CD8 T-cell: 19 nTPM
NK-cell: 19 nTPM

Brain region

hypothalamus: 80 nTPM
pons: 74 nTPM
white matter: 74 nTPM
thalamus: 72 nTPM
spinal cord: 72 nTPM
midbrain: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.85
gnomAD missense Z: 1.93
DepMap mean gene effect: -0.9
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMPK1 as an antibody target. Whether an autoantibody or antibody against CMPK1 could matter depends on whether native CMPK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMPK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMPK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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