Seroatlas · Human Serome Atlas

NTPCR

Cancer-related nucleoside-triphosphatase

Also known as: C1orf57, HCR-NTPase, MGC13186, NTPCR_HUMAN, THEP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSD7
Gene: NTPCR
Ensembl: ENSG00000135778
Chromosome: 1
Canonical length: 190 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q9BSD7|NTPCR
     1  MARHVFLTGP PGVGKTTLIH KASEVLKSSG VPVDGFYTEE VRQGGRRIGF DVVTLSGTRG
    61  PLSRVGLEPP PGKRECRVGQ YVVDLTSFEQ LALPVLRNAD CSSGPGQRVC VIDEIGKMEL
   121  FSQLFIQAVR QTLSTPGTII LGTIPVPKGK PLALVEEIRN RKDVKVFNVT KENRNHLLPD
   181  IVTCVQSSRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTPCR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 13 nTPM
tongue: 11 nTPM
choroid plexus: 10 nTPM
cerebral cortex: 7.9 nTPM
basal ganglia: 7.7 nTPM
midbrain: 7.4 nTPM

Single-cell type

late primary spermatocytes: 120 nCPM
choroid plexus epithelial cells: 103 nCPM
retinal pigment epithelial cells: 102 nCPM
esophageal suprabasal cells: 98 nCPM
cytotrophoblasts: 93 nCPM
oocytes: 88 nCPM

Immune cell

naive CD4 T-cell: 1.2 nTPM
T-reg: 1.1 nTPM
naive CD8 T-cell: 1 nTPM
memory CD4 T-cell: 0.9 nTPM
neutrophil: 0.9 nTPM
MAIT T-cell: 0.7 nTPM

Brain region

pons: 20 nTPM
choroid plexus: 18 nTPM
hypothalamus: 17 nTPM
medulla oblongata: 16 nTPM
spinal cord: 16 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

AAA+ ATPase domain
P-loop containing nucleoside triphosphate hydrolase
Nucleoside-triphosphatase, THEP1 type
NTPase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTPCR as an antibody target. Whether an autoantibody or antibody against NTPCR could matter depends on whether native NTPCR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTPCR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NTPCR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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