Seroatlas · Human Serome Atlas

KIF23

Kinesin-like protein KIF23

Also known as: KIF23_HUMAN, KNSL5, MKLP-1, MKLP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q02241
Gene: KIF23
Ensembl: ENSG00000137807
Chromosome: 15
Canonical length: 960 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody ring,Mitotic spindle,Mid piece,Principal piece,Annulus

OverviewNCBI Gene

The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

960 residues, UniProt reviewed canonical sequence.

>Q02241|KIF23
     1  MKSARAKTPR KPTVKKGSQT NLKDPVGVYC RVRPLGFPDQ ECCIEVINNT TVQLHTPEGY
    61  RLNRNGDYKE TQYSFKQVFG THTTQKELFD VVANPLVNDL IHGKNGLLFT YGVTGSGKTH
   121  TMTGSPGEGG LLPRCLDMIF NSIGSFQAKR YVFKSNDRNS MDIQCEVDAL LERQKREAMP
   181  NPKTSSSKRQ VDPEFADMIT VQEFCKAEEV DEDSVYGVFV SYIEIYNNYI YDLLEEVPFD
   241  PIKPKPPQSK LLREDKNHNM YVAGCTEVEV KSTEEAFEVF WRGQKKRRIA NTHLNRESSR
   301  SHSVFNIKLV QAPLDADGDN VLQEKEQITI SQLSLVDLAG SERTNRTRAE GNRLREAGNI
   361  NQSLMTLRTC MDVLRENQMY GTNKMVPYRD SKLTHLFKNY FDGEGKVRMI VCVNPKAEDY
   421  EENLQVMRFA EVTQEVEVAR PVDKAICGLT PGRRYRNQPR GPVGNEPLVT DVVLQSFPPL
   481  PSCEILDIND EQTLPRLIEA LEKRHNLRQM MIDEFNKQSN AFKALLQEFD NAVLSKENHM
   541  QGKLNEKEKM ISGQKLEIER LEKKNKTLEY KIEILEKTTT IYEEDKRNLQ QELETQNQKL
   601  QRQFSDKRRL EARLQGMVTE TTMKWEKECE RRVAAKQLEM QNKLWVKDEK LKQLKAIVTE
   661  PKTEKPERPS RERDREKVTQ RSVSPSPVPL SSNYIAQISN GQQLMSQPQL HRRSNSCSSI
   721  SVASCISEWE QKIPTYNTPL KVTSIARRRQ QEPGQSKTCI VSDRRRGMYW TEGREVVPTF
   781  RNEIEIEEDH CGRLLFQPDQ NAPPIRLRHR RSRSAGDRWV DHKPASNMQT ETVMQPHVPH
   841  AITVSVANEK ALAKCEKYML THQELASDGE IETKLIKGDI YKTRGGGQSV QFTDIETLKQ
   901  ESPNGSRKRR SSTVAPAQPD GAESEWTDVE TRCSVAVEMR AGSQLGPGYQ HHAQPKRKKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 20 nTPM
thymus: 15 nTPM
testis: 9.9 nTPM
tonsil: 9.2 nTPM
lymph node: 7.4 nTPM
placenta: 6 nTPM

Single-cell type

erythrocyte progenitors: 87 nCPM
monocyte progenitors: 74 nCPM
late primary spermatocytes: 61 nCPM
migrating cytotrophoblasts: 53 nCPM
extravillous trophoblasts: 49 nCPM
early primary spermatocytes: 46 nCPM

Immune cell

eosinophil: 4.6 nTPM
classical monocyte: 1.2 nTPM
T-reg: 1.2 nTPM
non-classical monocyte: 0.7 nTPM
intermediate monocyte: 0.5 nTPM
total PBMC: 0.3 nTPM

Brain region

choroid plexus: 2.9 nTPM
thalamus: 0.6 nTPM
pons: 0.5 nTPM
amygdala: 0.4 nTPM
cerebral cortex: 0.4 nTPM
hippocampal formation: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF23.

Disease | AllUniProt

Conditions KIF23 is implicated in, by any mechanism.

Anemia, congenital dyserythropoietic, 3A (CDAN3A) MIM:105600

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 425 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Congenital dyserythropoietic anemia, type III
Microcephaly

Disease | ImmuneIEDB

Conditions an epitope on KIF23 was assayed in.

viral infectious disease T cell
berylliosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 2.08
DepMap mean gene effect: -2.08
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Kinesin motor domain
Kinesin motor domain, conserved site
P-loop containing nucleoside triphosphate hydrolase
Kinesin-like protein
Kinesin motor domain superfamily
Kinesin motor domain
Kinesin-like protein Kif23, Arf6-interacting domain
Kinesin-like protein Kif23, Arf6-interacting domain superfamily
Arf6-interacting domain of mitotic kinesin-like protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF23 as an antibody target. Whether an autoantibody or antibody against KIF23 could matter depends on whether native KIF23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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