Seroatlas · Human Serome Atlas

KIF25

Kinesin-like protein KIF25

Also known as: KIF25_HUMAN, KNSL3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UIL4
Gene
KIF25
Ensembl
ENSG00000125337
Chromosome
6
Canonical length
384 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homotetramer

OverviewNCBI Gene

The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>Q9UIL4|KIF25
     1  MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL TSLLDGYNVC
    61  VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV AEELFRLILE NTSRSPKVEV
   121  SIVEVYNNDI FDLLAKDSIA AVSGVKREVV TAKDGRTEVA LLASEAVGSA SKLMELVHGG
   181  LQLRAKHPTL VHADSSRSHL IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA
   241  SQGALAPQLV PGNPAGHAEQ VQARLQLVDS AGSECVGVSG VTGLALREMA CISRSLAALA
   301  GVLGALLEHR GHAPYRNSRL THLLQDCLGG DAKLLVILCI SPSQRHLAQT LQGLGFGIRA
   361  RQVQRGPARK KPPSSQTEGK RRPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
6.4 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 6.4 nTPM
  • spinal cord: 2.4 nTPM
  • retina: 2.3 nTPM
  • midbrain: 2 nTPM
  • cerebral cortex: 1.4 nTPM
  • hippocampal formation: 1.3 nTPM

Single-cell type

  • retinal pigment epithelial cells: 38 nCPM
  • bergmann glia: 18 nCPM
  • vascular endothelial cells: 14 nCPM
  • brain inhibitory neurons: 8.3 nCPM
  • epididymal clear cells: 8.2 nCPM
  • retinal bipolar cells: 7.9 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 8.6 nTPM
  • pons: 6.2 nTPM
  • medulla oblongata: 5.5 nTPM
  • white matter: 5.5 nTPM
  • cerebral cortex: 5.1 nTPM
  • thalamus: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.57
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF25 as an antibody target. Whether an autoantibody or antibody against KIF25 could matter depends on whether native KIF25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF25. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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