CARD14

Protein identityUniProt · HPA

UniProt accession

Q9BXL6

Gene

CARD14

Ensembl

ENSG00000141527

Chromosome

17

Canonical length

1004 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

1004 residues, UniProt reviewed canonical sequence.

>Q9BXL6|CARD14
     1  MGELCRRDSA LTALDEETLW EMMESHRHRI VRCICPSRLT PYLRQAKVLC QLDEEEVLHS
    61  PRLTNSAMRA GHLLDLLKTR GKNGAIAFLE SLKFHNPDVY TLVTGLQPDV DFSNFSGLME
   121  TSKLTECLAG AIGSLQEELN QEKGQKEVLL RRCQQLQEHL GLAETRAEGL HQLEADHSRM
   181  KREVSAHFHE VLRLKDEMLS LSLHYSNALQ EKELAASRCR SLQEELYLLK QELQRANMVS
   241  SCELELQEQS LRTASDQESG DEELNRLKEE NEKLRSLTFS LAEKDILEQS LDEARGSRQE
   301  LVERIHSLRE RAVAAERQRE QYWEEKEQTL LQFQKSKMAC QLYREKVNAL QAQVCELQKE
   361  RDQAYSARDS AQREISQSLV EKDSLRRQVF ELTDQVCELR TQLRQLQAEP PGVLKQEART
   421  REPCPREKQR LVRMHAICPR DDSDCSLVSS TESQLLSDLS ATSSRELVDS FRSSSPAPPS
   481  QQSLYKRVAE DFGEEPWSFS SCLEIPEGDP GALPGAKAGD PHLDYELLDT ADLPQLESSL
   541  QPVSPGRLDV SESGVLMRRR PARRILSQVT MLAFQGDALL EQISVIGGNL TGIFIHRVTP
   601  GSAADQMALR PGTQIVMVDY EASEPLFKAV LEDTTLEEAV GLLRRVDGFC CLSVKVNTDG
   661  YKRLLQDLEA KVATSGDSFY IRVNLAMEGR AKGELQVHCN EVLHVTDTMF QGCGCWHAHR
   721  VNSYTMKDTA AHGTIPNYSR AQQQLIALIQ DMTQQCTVTR KPSSGGPQKL VRIVSMDKAK
   781  ASPLRLSFDR GQLDPSRMEG SSTCFWAESC LTLVPYTLVR PHRPARPRPV LLVPRAVGKI
   841  LSEKLCLLQG FKKCLAEYLS QEEYEAWSQR GDIIQEGEVS GGRCWVTRHA VESLMEKNTH
   901  ALLDVQLDSV CTLHRMDIFP IVIHVSVNEK MAKKLKKGLQ RLGTSEEQLL EAARQEEGDL
   961  DRAPCLYSSL APDGWSDLDG LLSCVRQAIA DEQKKVVWTE QSPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CARD14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

9.9 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CARD14.

Disease | AllUniProt

Conditions CARD14 is implicated in, by any mechanism.

• Psoriasis 2 (PSORS2) MIM:602723
• Pityriasis rubra pilaris (PRP) MIM:173200

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 1,417 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Psoriasis 2
• Pityriasis rubra pilaris
• Papulosquamous eruptions
• PSORIASIS 2, PUSTULAR

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0

gnomAD missense Z

0.61

DepMap mean gene effect

-0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• activation of NF-kappaB-inducing kinase activity
• apoptotic process
• negative regulation of apoptotic process
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of NF-kappaB transcription factor activity
• positive regulation of protein phosphorylation
• regulation of immune response
• tumor necrosis factor-mediated signaling pathway

Molecular functions

• CARD domain binding

Cellular components

• aggresome
• cytoplasm
• cytosol
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• CARD domain
• PDZ domain
• Guanylate kinase-like domain
• Death-like domain superfamily
• P-loop containing nucleoside triphosphate hydrolase
• PDZ superfamily
• Caspase recruitment domain

KeywordsUniProt

• Apoptosis
• Coiled coil
• Cytoplasm
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of CARD14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRAF2
• TRAF3
• TRAF6
• BCL10