Seroatlas · Human Serome Atlas

SULT1A2

Sulfotransferase 1A2

Also known as: HAST4, ST1A2_HUMAN, STP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50226
Gene: SULT1A2
Ensembl: ENSG00000197165
Chromosome: 16
Canonical length: 295 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>P50226|SULT1A2
     1  MELIQDISRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG TTWVSQILDM
    61  IYQGGDLEKC HRAPIFMRVP FLEFKVPGIP SGMETLKNTP APRLLKTHLP LALLPQTLLD
   121  QKVKVVYVAR NAKDVAVSYY HFYHMAKVYP HPGTWESFLE KFMAGEVSYG SWYQHVQEWW
   181  ELSRTHPVLY LFYEDMKENP KREIQKILEF VGRSLPEETV DLMVEHTSFK EMKKNPMTNY
   241  TTVRREFMDH SISPFMRKGM AGDWKTTFTV AQNERFDADY AKKMAGCSLS FRSEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SULT1A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

duodenum: 49 nTPM
liver: 48 nTPM
small intestine: 45 nTPM
colon: 13 nTPM
rectum: 13 nTPM
lung: 7.2 nTPM

Single-cell type

enterocytes: 240 nCPM
colonocytes: 52 nCPM
epididymal efferent duct absorptive cells: 27 nCPM
podocytes: 13 nCPM
hepatocytes: 9.8 nCPM
enteric transient amplifying cells: 6.9 nCPM

Immune cell

neutrophil: 15 nTPM
classical monocyte: 11 nTPM
intermediate monocyte: 8.7 nTPM
total PBMC: 5.4 nTPM
non-classical monocyte: 4.7 nTPM
myeloid DC: 4.1 nTPM

Brain region

cerebellum: 6.1 nTPM
cerebral cortex: 4.8 nTPM
amygdala: 4.2 nTPM
hippocampal formation: 4.1 nTPM
pons: 3.9 nTPM
basal ganglia: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -0.85
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SULT1A2 as an antibody target. Whether an autoantibody or antibody against SULT1A2 could matter depends on whether native SULT1A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SULT1A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SULT1A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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