Seroatlas · Human Serome Atlas

GNA13

Guanine nucleotide-binding protein subunit alpha-13

Also known as: G13, GNA13_HUMAN, MGC46138

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14344
Gene: GNA13
Ensembl: ENSG00000120063
Chromosome: 17
Canonical length: 377 aa
Protein class: Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables G protein activity. Involved in Rho-activating G protein-coupled receptor signaling pathway. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q14344|GNA13
     1  MADFLPSRSV LSVCFPGCLL TSGEAEQQRK SKEIDKCLSR EKTYVKRLVK ILLLGAGESG
    61  KSTFLKQMRI IHGQDFDQRA REEFRPTIYS NVIKGMRVLV DAREKLHIPW GDNSNQQHGD
   121  KMMSFDTRAP MAAQGMVETR VFLQYLPAIR ALWADSGIQN AYDRRREFQL GESVKYFLDN
   181  LDKLGEPDYI PSQQDILLAR RPTKGIHEYD FEIKNVPFKM VDVGGQRSER KRWFECFDSV
   241  TSILFLVSSS EFDQVLMEDR LTNRLTESLN IFETIVNNRV FSNVSIILFL NKTDLLEEKV
   301  QIVSIKDYFL EFEGDPHCLR DVQKFLVECF RNKRRDQQQK PLYHHFTTAI NTENIRLVFR
   361  DVKDTILHDN LKQLMLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNA13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 136 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 136 nTPM
thymus: 47 nTPM
lymph node: 44 nTPM
tonsil: 42 nTPM
appendix: 39 nTPM
placenta: 37 nTPM

Single-cell type

neutrophils: 778 nCPM
cdc: 550 nCPM
monocytes: 428 nCPM
macrophages: 397 nCPM
platelets: 284 nCPM
innate lymphoid cells: 248 nCPM

Immune cell

neutrophil: 14 nTPM
intermediate monocyte: 13 nTPM
T-reg: 9.8 nTPM
non-classical monocyte: 8.5 nTPM
eosinophil: 7.7 nTPM
basophil: 7.4 nTPM

Brain region

white matter: 73 nTPM
medulla oblongata: 65 nTPM
hypothalamus: 59 nTPM
spinal cord: 57 nTPM
cerebellum: 55 nTPM
thalamus: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.87
gnomAD missense Z: 2.71
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNA13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNA13 as an antibody target. Whether an autoantibody or antibody against GNA13 could matter depends on whether native GNA13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNA13 is annotated at the cell surface, where native GNA13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNA13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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