Seroatlas · Human Serome Atlas

DHX15

ATP-dependent RNA helicase DHX15

Also known as: DBP1, DDX15, DHX15_HUMAN, HRH2, PRP43, PRPF43, PrPp43p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43143
Gene
DHX15
Ensembl
ENSG00000109606
Chromosome
4
Canonical length
795 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

795 residues, UniProt reviewed canonical sequence.

>O43143|DHX15
     1  MSKRHRLDLG EDYPSGKKRA GTDGKDRDRD RDREDRSKDR DRERDRGDRE REREKEKEKE
    61  LRASTNAMLI SAGLPPLKAS HSAHSTHSAH STHSTHSAHS THAGHAGHTS LPQCINPFTN
   121  LPHTPRYYDI LKKRLQLPVW EYKDRFTDIL VRHQSFVLVG ETGSGKTTQI PQWCVEYMRS
   181  LPGPKRGVAC TQPRRVAAMS VAQRVADEMD VMLGQEVGYS IRFEDCSSAK TILKYMTDGM
   241  LLREAMNDPL LERYGVIILD EAHERTLATD ILMGVLKEVV RQRSDLKVIV MSATLDAGKF
   301  QIYFDNCPLL TIPGRTHPVE IFYTPEPERD YLEAAIRTVI QIHMCEEEEG DLLLFLTGQE
   361  EIDEACKRIK REVDDLGPEV GDIKIIPLYS TLPPQQQQRI FEPPPPKKQN GAIGRKVVVS
   421  TNIAETSLTI DGVVFVIDPG FAKQKVYNPR IRVESLLVTA ISKASAQQRA GRAGRTRPGK
   481  CFRLYTEKAY KTEMQDNTYP EILRSNLGSV VLQLKKLGID DLVHFDFMDP PAPETLMRAL
   541  ELLNYLAALN DDGDLTELGS MMAEFPLDPQ LAKMVIASCD YNCSNEVLSI TAMLSVPQCF
   601  VRPTEAKKAA DEAKMRFAHI DGDHLTLLNV YHAFKQNHES VQWCYDNFIN YRSLMSADNV
   661  RQQLSRIMDR FNLPRRSTDF TSRDYYINIR KALVTGYFMQ VAHLERTGHY LTVKDNQVVQ
   721  LHPSTVLDHK PEWVLYNEFV LTTKNYIRTC TDIKPEWLVK IAPQYYDMSN FPQCEAKRQL
   781  DRIIAKLQSK EYSQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHX15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 74 nTPM
  • bone marrow: 74 nTPM
  • tonsil: 67 nTPM
  • urinary bladder: 61 nTPM
  • lymph node: 56 nTPM
  • rectum: 54 nTPM

Single-cell type

  • endometrial glandular cells: 230 nCPM
  • neutrophil progenitors: 189 nCPM
  • monocyte progenitors: 183 nCPM
  • endometrial luminal cells: 179 nCPM
  • urothelial cells: 165 nCPM
  • erythrocyte progenitors: 164 nCPM

Immune cell

  • basophil: 58 nTPM
  • MAIT T-cell: 40 nTPM
  • myeloid DC: 39 nTPM
  • non-classical monocyte: 39 nTPM
  • T-reg: 39 nTPM
  • NK-cell: 37 nTPM

Brain region

  • cerebellum: 67 nTPM
  • choroid plexus: 66 nTPM
  • white matter: 63 nTPM
  • basal ganglia: 51 nTPM
  • medulla oblongata: 50 nTPM
  • thalamus: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.11
gnomAD pLI
1
gnomAD missense Z
5.63
DepMap mean gene effect
-1.52
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DHX15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHX15 as an antibody target. Whether an autoantibody or antibody against DHX15 could matter depends on whether native DHX15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHX15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHX15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DHX15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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