DHX58
ATP-dependent RNA helicase DHX58
Also known as: D11LGP2, DHX58_HUMAN, LGP2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96C10
- Gene
- DHX58
- Ensembl
- ENSG00000108771
- Chromosome
- 17
- Canonical length
- 678 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Golgi apparatus,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables several functions, including ATP hydrolysis activity; RNA binding activity; and zinc ion binding activity. Involved in negative regulation of type I interferon production and regulation of innate immune response. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
678 residues, UniProt reviewed canonical sequence.
>Q96C10|DHX58
1 MELRSYQWEV IMPALEGKNI IIWLPTGAGK TRAAAYVAKR HLETVDGAKV VVLVNRVHLV
61 TQHGEEFRRM LDGRWTVTTL SGDMGPRAGF GHLARCHDLL ICTAELLQMA LTSPEEEEHV
121 ELTVFSLIVV DECHHTHKDT VYNVIMSQYL ELKLQRAQPL PQVLGLTASP GTGGASKLDG
181 AINHVLQLCA NLDTWCIMSP QNCCPQLQEH SQQPCKQYNL CHRRSQDPFG DLLKKLMDQI
241 HDHLEMPELS RKFGTQMYEQ QVVKLSEAAA LAGLQEQRVY ALHLRRYNDA LLIHDTVRAV
301 DALAALQDFY HREHVTKTQI LCAERRLLAL FDDRKNELAH LATHGPENPK LEMLEKILQR
361 QFSSSNSPRG IIFTRTRQSA HSLLLWLQQQ QGLQTVDIRA QLLIGAGNSS QSTHMTQRDQ
421 QEVIQKFQDG TLNLLVATSV AEEGLDIPHC NVVVRYGLLT NEISMVQARG RARADQSVYA
481 FVATEGSREL KRELINEALE TLMEQAVAAV QKMDQAEYQA KIRDLQQAAL TKRAAQAAQR
541 ENQRQQFPVE HVQLLCINCM VAVGHGSDLR KVEGTHHVNV NPNFSNYYNV SRDPVVINKV
601 FKDWKPGGVI SCRNCGEVWG LQMIYKSVKL PVLKVRSMLL ETPQGRIQAK KWSRVPFSVP
661 DFDFLQHCAE NLSDLSLDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DHX58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 18 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 18 nTPM
- spleen: 17 nTPM
- liver: 14 nTPM
- ovary: 12 nTPM
- lymph node: 12 nTPM
- thymus: 12 nTPM
Single-cell type
- late primary spermatocytes: 45 nCPM
- oocytes: 32 nCPM
- hepatocytes: 17 nCPM
- late spermatids: 16 nCPM
- peritubular myoid cells: 11 nCPM
- astrocytes: 11 nCPM
Immune cell
- intermediate monocyte: 9.7 nTPM
- non-classical monocyte: 8.6 nTPM
- classical monocyte: 7.7 nTPM
- eosinophil: 6.9 nTPM
- NK-cell: 6.8 nTPM
- myeloid DC: 5.9 nTPM
Brain region
- spinal cord: 14 nTPM
- medulla oblongata: 13 nTPM
- pons: 12 nTPM
- white matter: 12 nTPM
- basal ganglia: 11 nTPM
- thalamus: 9.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.1
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.52
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antiviral innate immune response
- cytoplasmic pattern recognition receptor signaling pathway
- negative regulation of innate immune response
- negative regulation of MDA-5 signaling pathway
- negative regulation of RIG-I signaling pathway
- negative regulation of type I interferon production
- positive regulation of MDA-5 signaling pathway
- positive regulation of RIG-I signaling pathway
- positive regulation of type I interferon production
- regulation of innate immune response
- response to bacterium
- response to virus
Molecular functions
- ATP binding
- ATP hydrolysis activity
- DNA binding
- double-stranded RNA binding
- RNA helicase activity
- single-stranded RNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Helicase, C-terminal domain-like
- Helicase/UvrB, N-terminal
- Helicase superfamily 1/2, ATP-binding domain
- RIG-I-like receptor, C-terminal regulatory domain
- P-loop containing nucleoside triphosphate hydrolase
- RIG-I-like receptor, C-terminal domain superfamily
- RIG-I-like receptor, C-terminal
- RIG-I-like Receptor (RLR) Helicase
- Helicase conserved C-terminal domain
- Type III restriction enzyme, res subunit
- C-terminal domain of RIG-I
- RIG-I receptor C-terminal domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of DHX58 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DHX58 as an antibody target. Whether an autoantibody or antibody against DHX58 could matter depends on whether native DHX58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DHX58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DHX58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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