Seroatlas · Human Serome Atlas

DDX19A

ATP-dependent RNA helicase DDX19A

Also known as: DD19A_HUMAN, DDX19L, FLJ11126

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUU7
Gene: DDX19A
Ensembl: ENSG00000168872
Chromosome: 16
Canonical length: 478 aa
Protein class: Enzymes, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q9NUU7|DDX19A
     1  MATDSWALAV DEQEAAVKSM TNLQIKEEKV KADTNGIIKT STTAEKTDEE EKEDRAAQSL
    61  LNKLIRSNLV DNTNQVEVLQ RDPNSPLYSV KSFEELRLKP QLLQGVYAMG FNRPSKIQEN
   121  ALPMMLAEPP QNLIAQSQSG TGKTAAFVLA MLSRVEPSDR YPQCLCLSPT YELALQTGKV
   181  IEQMGKFYPE LKLAYAVRGN KLERGQKISE QIVIGTPGTV LDWCSKLKFI DPKKIKVFVL
   241  DEADVMIATQ GHQDQSIRIQ RMLPRNCQML LFSATFEDSV WKFAQKVVPD PNVIKLKREE
   301  ETLDTIKQYY VLCSSRDEKF QALCNLYGAI TIAQAMIFCH TRKTASWLAA ELSKEGHQVA
   361  LLSGEMMVEQ RAAVIERFRE GKEKVLVTTN VCARGIDVEQ VSVVINFDLP VDKDGNPDNE
   421  TYLHRIGRTG RFGKRGLAVN MVDSKHSMNI LNRIQEHFNK KIERLDTDDL DEIEKIAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDX19A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 57 nTPM
tongue: 36 nTPM
smooth muscle: 25 nTPM
parathyroid gland: 23 nTPM
blood vessel: 23 nTPM
placenta: 22 nTPM

Single-cell type

cytotrophoblasts: 21 nCPM
migrating cytotrophoblasts: 20 nCPM
esophageal basal cells: 19 nCPM
alveolar cells type 1: 17 nCPM
cholangiocytes: 17 nCPM
leydig cells: 17 nCPM

Immune cell

myeloid DC: 11 nTPM
basophil: 9.8 nTPM
classical monocyte: 8.6 nTPM
intermediate monocyte: 8.1 nTPM
non-classical monocyte: 7.6 nTPM
naive CD8 T-cell: 7.5 nTPM

Brain region

choroid plexus: 17 nTPM
thalamus: 17 nTPM
pons: 17 nTPM
cerebellum: 17 nTPM
cerebral cortex: 16 nTPM
hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.84
gnomAD missense Z: 2.37
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDX19A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MIF4GD

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDX19A as an antibody target. Whether an autoantibody or antibody against DDX19A could matter depends on whether native DDX19A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDX19A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDX19A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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