Seroatlas · Human Serome Atlas

HS3ST3A1

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

Also known as: 30ST3A1, 3OST3A1, HS3SA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y663
Gene
HS3ST3A1
Ensembl
ENSG00000153976
Chromosome
17
Canonical length
406 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Microtubules

OverviewNCBI Gene

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9Y663|HS3ST3A1
     1  MAPPGPASAL STSAEPLSRS IFRKFLLMLC SLLTSLYVFY CLAERCQTLS GPVVGLSGGG
    61  EEAGAPGGGV LAGGPRELAV WPAAAQRKRL LQLPQWRRRR PPAPRDDGEE AAWEEESPGL
   121  SGGPGGSGAG STVAEAPPGT LALLLDEGSK QLPQAIIIGV KKGGTRALLE FLRVHPDVRA
   181  VGAEPHFFDR SYDKGLAWYR DLMPRTLDGQ ITMEKTPSYF VTREAPARIS AMSKDTKLIV
   241  VVRDPVTRAI SDYTQTLSKR PDIPTFESLT FKNRTAGLID TSWSAIQIGI YAKHLEHWLR
   301  HFPIRQMLFV SGERLISDPA GELGRVQDFL GLKRIITDKH FYFNKTKGFP CLKKAEGSSR
   361  PHCLGKTKGR THPEIDREVV RRLREFYRPF NLKFYQMTGH DFGWDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HS3ST3A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
8 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 8 nTPM
  • spleen: 6.1 nTPM
  • seminal vesicle: 4.7 nTPM
  • esophagus: 4.4 nTPM
  • cervix: 3.5 nTPM
  • prostate: 3.2 nTPM

Single-cell type

  • retinal horizontal cells: 601 nCPM
  • choroid plexus epithelial cells: 262 nCPM
  • podocytes: 119 nCPM
  • leydig cells: 117 nCPM
  • esophageal suprabasal cells: 95 nCPM
  • pituitary stem cells: 79 nCPM

Immune cell

  • T-reg: 2.2 nTPM
  • plasmacytoid DC: 1.7 nTPM
  • gdT-cell: 0.7 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • naive CD4 T-cell: 0.5 nTPM
  • naive CD8 T-cell: 0.5 nTPM

Brain region

  • medulla oblongata: 14 nTPM
  • spinal cord: 8.8 nTPM
  • choroid plexus: 8.2 nTPM
  • midbrain: 4 nTPM
  • pons: 3.8 nTPM
  • cerebral cortex: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0.01
gnomAD missense Z
0.42
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HS3ST3A1 as an antibody target. Whether an autoantibody or antibody against HS3ST3A1 could matter depends on whether native HS3ST3A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HS3ST3A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HS3ST3A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HS3ST3A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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