Seroatlas · Human Serome Atlas

KIF4B

Chromosome-associated kinesin KIF4B

Also known as: KIF4B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2VIQ3
Gene
KIF4B
Ensembl
ENSG00000226650
Chromosome
5
Canonical length
1234 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Midbody,Acrosome,Equatorial segment,Mid piece,Principal piece

OverviewNCBI Gene

This gene is an intronless retrocopy of kinesin family member 4A. The protein encoded by this gene is a microtubule-based motor protein that plays vital roles in anaphase spindle dynamics and cytokinesis. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

1234 residues, UniProt reviewed canonical sequence.

>Q2VIQ3|KIF4B
     1  MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGETQ VVVGTDKSFT YDFVFDPCTE
    61  QEEVFNKAVA PLIKGIFKGY NATVLAYGQT GSGKTYSMGG AYTAEQENEP TVGIIPRVIQ
   121  LLFKEIDKKS DFEFTLKVSY LEIYNEEILD LLCPSREKAQ INIREDPKEG IKIVGLTEKT
   181  VLVALDTVSC LEQGNNSRTV ASTAMNSQSS RSHAIFTISI EQRKKSDKNC SFRSKLHLVD
   241  LAGSERQKKT KAEGDRLKEG ININRGLLCL GNVISALGDD KKGSFVPYRD SKLTRLLQDS
   301  LGGNSHTLMI ACVSPADSNL EETLSTLRYA DRARKIKNKP IVNIDPHTAE LNHLKQQVQQ
   361  LQVLLLQAHG GTLPGSINAE PSENLQSLME KNQSLVEENE KLSRCLSKAA GQTAQMLERI
   421  ILTEQVNEKL NAKLEELRQH VACKLDLQKL VETLEDQELK ENVEIICNLQ QLITQLSDET
   481  VACTAAAIDT AVEEEAQVET SPETSRSSDA FTTQHALHQA QMSKEVVELN NALALKEALV
   541  RKMTQNDNQL QPIQFQYQDN IKNLELEVIN LQKEKEELVR ELQTAKKNVN QAKLSEHRHK
   601  LLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI WMMKNQRVQL MRQMKEDAEK
   661  FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSSVL RRKTEEAAAA NKRLKDALQK
   721  QREVTDKRKE TQSHGKEGIA ARVRNWLGNE IEVMVSTEEA KRHLNDLLED RKILAQDVVQ
   781  LKEKKESREN PPPKLRKCTF SLSEVHGQVL ESEDCITKQI ESLETEMELR SAQIADLQQK
   841  LLDAESEDRP KQCWENIATI LEAKCALKYL IGELVSSKIH VTKLENSLRQ SKASCADMQK
   901  MLFEEQNHFS EIETELQAEL VRMEQQHQEK VLYLVSQLQE SQMAEKQLEK SASEKEQQLV
   961  STLQCQDEEL EKMREVCEQN QQLLQENEII KQKLILLQVA SRQKHLPNDT LLSPDSSFEY
  1021  IPPKPKPSRV KEKFLEQSMD IEDLKYCSEH SVNEHEDGDG DGDSDEGDDE EWKPTKLVKV
  1081  SRKNIQGCSC KGWCGNKQCG CRKQKSDCGV DCSCDPTKCR NRQQGKDSLG TVEQTQDSEG
  1141  SFKLEDPTEV TPGLSFFNPV CATPNSKILK EMCDMEQVLS KKTAPAPSPF DLPESKHGAT
  1201  EYQQNKPPGK KKKRALASNT SFFSGCSPIE EEAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
3.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3.3 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • late primary spermatocytes: 22 nCPM
  • late spermatids: 6.8 nCPM
  • early spermatids: 4.5 nCPM
  • cone photoreceptor cells: 2.1 nCPM
  • schwann cells: 1 nCPM
  • undifferentiated spermatogonia: 0.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.8 nTPM
  • pons: 0.8 nTPM
  • white matter: 0.7 nTPM
  • cerebellum: 0.6 nTPM
  • medulla oblongata: 0.6 nTPM
  • amygdala: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
-0.62
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF4B as an antibody target. Whether an autoantibody or antibody against KIF4B could matter depends on whether native KIF4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF4B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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