GBP1

Protein identityUniProt · HPA

UniProt accession

P32455

Gene

GBP1

Ensembl

ENSG00000117228

Chromosome

1

Canonical length

592 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>P32455|GBP1
     1  MASEIHMTGP MCLIENTNGR LMANPEALKI LSAITQPMVV VAIVGLYRTG KSYLMNKLAG
    61  KKKGFSLGST VQSHTKGIWM WCVPHPKKPG HILVLLDTEG LGDVEKGDNQ NDSWIFALAV
   121  LLSSTFVYNS IGTINQQAMD QLYYVTELTH RIRSKSSPDE NENEVEDSAD FVSFFPDFVW
   181  TLRDFSLDLE ADGQPLTPDE YLTYSLKLKK GTSQKDETFN LPRLCIRKFF PKKKCFVFDR
   241  PVHRRKLAQL EKLQDEELDP EFVQQVADFC SYIFSNSKTK TLSGGIQVNG PRLESLVLTY
   301  VNAISSGDLP CMENAVLALA QIENSAAVQK AIAHYEQQMG QKVQLPTETL QELLDLHRDS
   361  EREAIEVFIR SSFKDVDHLF QKELAAQLEK KRDDFCKQNQ EASSDRCSAL LQVIFSPLEE
   421  EVKAGIYSKP GGYRLFVQKL QDLKKKYYEE PRKGIQAEEI LQTYLKSKES MTDAILQTDQ
   481  TLTEKEKEIE VERVKAESAQ ASAKMLQEMQ RKNEQMMEQK ERSYQEHLKQ LTEKMENDRV
   541  QLLKEQERTL ALKLQEQEQL LKEGFQKESR IMKNEIQDLQ TKMRRRKACT IS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

82 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.23

gnomAD pLI

0

gnomAD missense Z

-0.45

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to interleukin-1
• cellular response to tumor necrosis factor
• cellular response to type II interferon
• cytolysis in another organism
• defense response to bacterium
• defense response to protozoan
• defense response to virus
• innate immune response
• negative regulation of ERK1 and ERK2 cascade
• negative regulation of interleukin-2 production
• negative regulation of protein localization to plasma membrane
• negative regulation of substrate adhesion-dependent cell spreading
• negative regulation of T cell receptor signaling pathway
• non-canonical inflammasome complex assembly
• positive regulation of pyroptotic inflammatory response
• protein localization to vacuole
• regulation of calcium-mediated signaling
• regulation of protein localization to plasma membrane

Molecular functions

• actin binding
• cytokine binding
• enzyme binding
• G protein activity
• GDP binding
• GDP phosphatase activity
• GTP binding
• GTPase activity
• Hsp90 protein binding
• identical protein binding
• lipopolysaccharide binding
• protein homodimerization activity
• spectrin binding

Cellular components

• actin cytoskeleton
• cytoplasm
• cytoplasmic vesicle
• cytoplasmic vesicle membrane
• cytosol
• extracellular region
• Golgi apparatus
• Golgi membrane
• plasma membrane
• symbiont cell surface
• vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• Guanylate-binding protein/Atlastin, C-terminal
• Guanylate-binding protein, N-terminal
• P-loop containing nucleoside triphosphate hydrolase
• GB1/RHD3-type guanine nucleotide-binding (G) domain
• Guanylate-binding protein, C-terminal domain superfamily
• Guanylate-binding protein, C-terminal
• Guanylate-binding protein, N-terminal domain
• Guanylate-binding protein, C-terminal domain

KeywordsUniProt

• Antiviral defense
• Cell membrane
• Cytoplasm
• Cytoplasmic vesicle
• Golgi apparatus
• GTP-binding
• Hydrolase
• Immunity
• Innate immunity
• Isopeptide bond
• Lipoprotein
• Membrane
• Methylation
• Nucleotide-binding
• Phosphoprotein
• Prenylation
• Secreted
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of GBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SQSTM1