RAB13
Ras-related protein Rab-13
Also known as: RAB13_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P51153
- Gene
- RAB13
- Ensembl
- ENSG00000143545
- Chromosome
- 1
- Canonical length
- 203 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]
Canonical amino-acid sequenceUniProt
203 residues, UniProt reviewed canonical sequence.
>P51153|RAB13
1 MAKAYDHLFK LLLIGDSGVG KTCLIIRFAE DNFNNTYIST IGIDFKIRTV DIEGKKIKLQ
61 VWDTAGQERF KTITTAYYRG AMGIILVYDI TDEKSFENIQ NWMKSIKENA SAGVERLLLG
121 NKCDMEAKRK VQKEQADKLA REHGIRFFET SAKSSMNVDE AFSSLARDIL LKSGGRRSGN
181 GNKPPSTDLK TCDKKNTNKC SLGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RAB13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 214 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 214 nTPM
- kidney: 156 nTPM
- adipose tissue: 144 nTPM
- blood vessel: 132 nTPM
- adrenal gland: 125 nTPM
- breast: 119 nTPM
Single-cell type
- papillary tip epithelial cells: 26 nCPM
- renal collecting duct principal cells: 25 nCPM
- loop of henle epithelial cells: 17 nCPM
- gastric chief cells: 11 nCPM
- renal collecting duct intercalated cells: 10 nCPM
- epididymal principal cells: 10 nCPM
Immune cell
- plasmacytoid DC: 13 nTPM
- myeloid DC: 11 nTPM
- classical monocyte: 7 nTPM
- total PBMC: 1.9 nTPM
- intermediate monocyte: 1 nTPM
- neutrophil: 0.8 nTPM
Brain region
- medulla oblongata: 55 nTPM
- choroid plexus: 48 nTPM
- hypothalamus: 47 nTPM
- midbrain: 40 nTPM
- spinal cord: 39 nTPM
- thalamus: 37 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.76
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 1.07
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- bicellular tight junction assembly
- cellular response to insulin stimulus
- cortical actin cytoskeleton organization
- endocytic recycling
- endosomal transport
- endothelial cell chemotaxis
- establishment of Sertoli cell barrier
- exocytosis
- Golgi to plasma membrane transport
- neuron projection development
- protein kinase A signaling
- protein localization to cell leading edge
- protein localization to plasma membrane
- protein transport
- trans-Golgi network to recycling endosome transport
Molecular functions
Cellular components
- bicellular tight junction
- cell junction
- cytoplasmic vesicle
- cytosol
- endocytic vesicle
- endosome
- extracellular exosome
- Golgi apparatus
- insulin-responsive compartment
- lamellipodium
- lateral plasma membrane
- neuron projection
- plasma membrane
- recycling endosome
- recycling endosome membrane
- synaptic vesicle
- trans-Golgi network
- trans-Golgi network transport vesicle
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RAB13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RAB13 as an antibody target. Whether an autoantibody or antibody against RAB13 could matter depends on whether native RAB13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RAB13 is annotated at the cell surface, where native RAB13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RAB13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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