Seroatlas · Human Serome Atlas

KIF3B

Kinesin-like protein KIF3B

Also known as: FLA8, KIAA0359, KIF3B_HUMAN, KLP-11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15066
Gene
KIF3B
Ensembl
ENSG00000101350
Chromosome
20
Canonical length
747 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium tip,Cytosol,Connecting piece,Flagellar centriole

OverviewNCBI Gene

The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>O15066|KIF3B
     1  MSKLKSSESV RVVVRCRPMN GKEKAASYDK VVDVDVKLGQ VSVKNPKGTA HEMPKTFTFD
    61  AVYDWNAKQF ELYDETFRPL VDSVLQGFNG TIFAYGQTGT GKTYTMEGIR GDPEKRGVIP
   121  NSFDHIFTHI SRSQNQQYLV RASYLEIYQE EIRDLLSKDQ TKRLELKERP DTGVYVKDLS
   181  SFVTKSVKEI EHVMNVGNQN RSVGATNMNE HSSRSHAIFV ITIECSEVGL DGENHIRVGK
   241  LNLVDLAGSE RQAKTGAQGE RLKEATKINL SLSALGNVIS ALVDGKSTHI PYRDSKLTRL
   301  LQDSLGGNAK TVMVANVGPA SYNVEETLTT LRYANRAKNI KNKPRVNEDP KDALLREFQE
   361  EIARLKAQLE KRSIGRRKRR EKRREGGGSG GGGEEEEEEG EEGEEEGDDK DDYWREQQEK
   421  LEIEKRAIVE DHSLVAEEKM RLLKEKEKKM EDLRREKDAA EMLGAKIKAM ESKLLVGGKN
   481  IVDHTNEQQK ILEQKRQEIA EQKRREREIQ QQMESRDEET LELKETYSSL QQEVDIKTKK
   541  LKKLFSKLQA VKAEIHDLQE EHIKERQELE QTQNELTREL KLKHLIIENF IPLEEKSKIM
   601  NRAFFDEEED HWKLHPITRL ENQQMMKRPV SAVGYKRPLS QHARMSMMIR PEARYRAENI
   661  VLLELDMPSR TTRDYEGPAI APKVQAALDA ALQDEDEIQV DASSFESTAN KKSKARPKSG
   721  RKSGSSSSSS GTPASQLYPQ SRGLVPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 44 nTPM
  • choroid plexus: 38 nTPM
  • kidney: 33 nTPM
  • cerebral cortex: 30 nTPM
  • retina: 29 nTPM
  • basal ganglia: 25 nTPM

Single-cell type

  • late spermatids: 156 nCPM
  • cone photoreceptor cells: 128 nCPM
  • enterocytes: 128 nCPM
  • respiratory ciliated cells: 119 nCPM
  • renal collecting duct intercalated cells: 117 nCPM
  • rod photoreceptor cells: 109 nCPM

Immune cell

  • non-classical monocyte: 3.3 nTPM
  • gdT-cell: 3.2 nTPM
  • memory B-cell: 3.2 nTPM
  • naive B-cell: 3.1 nTPM
  • memory CD8 T-cell: 3 nTPM
  • MAIT T-cell: 2.6 nTPM

Brain region

  • choroid plexus: 69 nTPM
  • hippocampal formation: 60 nTPM
  • thalamus: 54 nTPM
  • cerebral cortex: 52 nTPM
  • basal ganglia: 49 nTPM
  • amygdala: 48 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF3B.

Disease | AllUniProt

Conditions KIF3B is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 93 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Retinitis pigmentosa 89

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.08
gnomAD missense Z
3
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF3B as an antibody target. Whether an autoantibody or antibody against KIF3B could matter depends on whether native KIF3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIF3B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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