Seroatlas · Human Serome Atlas

KIF20A

Kinesin-like protein KIF20A

Also known as: KI20A_HUMAN, MKLP2, RAB6KIFL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95235
Gene: KIF20A
Ensembl: ENSG00000112984
Chromosome: 5
Canonical length: 890 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytokinetic bridge,Cleavage furrow,Mitotic spindle

OverviewNCBI Gene

Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; midbody; and mitotic spindle. Implicated in familial restrictive cardiomyopathy 6. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

890 residues, UniProt reviewed canonical sequence.

>O95235|KIF20A
     1  MSQGILSPPA GLLSDDDVVV SPMFESTAAD LGSVVRKNLL SDCSVVSTSL EDKQQVPSED
    61  SMEKVKVYLR VRPLLPSELE RQEDQGCVRI ENVETLVLQA PKDSFALKSN ERGIGQATHR
   121  FTFSQIFGPE VGQASFFNLT VKEMVKDVLK GQNWLIYTYG VTNSGKTHTI QGTIKDGGIL
   181  PRSLALIFNS LQGQLHPTPD LKPLLSNEVI WLDSKQIRQE EMKKLSLLNG GLQEEELSTS
   241  LKRSVYIESR IGTSTSFDSG IAGLSSISQC TSSSQLDETS HRWAQPDTAP LPVPANIRFS
   301  IWISFFEIYN ELLYDLLEPP SQQRKRQTLR LCEDQNGNPY VKDLNWIHVQ DAEEAWKLLK
   361  VGRKNQSFAS THLNQNSSRS HSIFSIRILH LQGEGDIVPK ISELSLCDLA GSERCKDQKS
   421  GERLKEAGNI NTSLHTLGRC IAALRQNQQN RSKQNLVPFR DSKLTRVFQG FFTGRGRSCM
   481  IVNVNPCAST YDETLHVAKF SAIASQLVHA PPMQLGFPSL HSFIKEHSLQ VSPSLEKGAK
   541  ADTGLDDDIE NEADISMYGK EELLQVVEAM KTLLLKERQE KLQLEMHLRD EICNEMVEQM
   601  QQREQWCSEH LDTQKELLEE MYEEKLNILK ESLTSFYQEE IQERDEKIEE LEALLQEARQ
   661  QSVAHQQSGS ELALRRSQRL AASASTQQLQ EVKAKLQQCK AELNSTTEEL HKYQKMLEPP
   721  PSAKPFTIDV DKKLEEGQKN IRLLRTELQK LGESLQSAER ACCHSTGAGK LRQALTTCDD
   781  ILIKQDQTLA ELQNNMVLVK LDLRKKAACI AEQYHTVLKL QGQVSAKKRL GTNQENQQPN
   841  QQPPGKKPFL RNLLPRTPTC QSSTDCSPYA RILRSRRSPL LKSGPFGKKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIF20A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

thymus: 23 nTPM
bone marrow: 13 nTPM
tonsil: 12 nTPM
testis: 11 nTPM
lymph node: 8 nTPM
esophagus: 6.3 nTPM

Single-cell type

monocyte progenitors: 39 nCPM
erythrocyte progenitors: 23 nCPM
early primary spermatocytes: 17 nCPM
gastric progenitor cells: 17 nCPM
migrating cytotrophoblasts: 15 nCPM
megakaryocyte progenitors: 14 nCPM

Immune cell

NK-cell: 6.7 nTPM
T-reg: 2.5 nTPM
memory CD8 T-cell: 0.3 nTPM
total PBMC: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
basophil: 0 nTPM

Brain region

thalamus: 1.4 nTPM
pons: 0.8 nTPM
choroid plexus: 0.6 nTPM
cerebellum: 0.5 nTPM
cerebral cortex: 0.5 nTPM
medulla oblongata: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIF20A.

Disease | AllUniProt

Conditions KIF20A is implicated in, by any mechanism.

Cardiomyopathy, familial restrictive 6 (RCM6) MIM:619433

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 576 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cardiomyopathy, familial restrictive, 6

Disease | ImmuneIEDB

Conditions an epitope on KIF20A was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 1.28
DepMap mean gene effect: -0.59
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIF20A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIF20A as an antibody target. Whether an autoantibody or antibody against KIF20A could matter depends on whether native KIF20A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIF20A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIF20A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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