Seroatlas · Human Serome Atlas

IFI44

Interferon-induced protein 44

Also known as: IFI44_HUMAN, MTAP44, p44, TLDC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCB0
Gene: IFI44
Ensembl: ENSG00000137965
Chromosome: 1
Canonical length: 444 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in immune response. Predicted to act upstream of or within cellular response to virus and response to bacterium. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>Q8TCB0|IFI44
     1  MAVTTRLTWL HEKILQNHFG GKRLSLLYKG SVHGFRNGVL LDRCCNQGPT LTVIYSEDHI
    61  IGAYAEESYQ EGKYASIILF ALQDTKISEW KLGLCTPETL FCCDVTKYNS PTNFQIDGRN
   121  RKVIMDLKTM ENLGLAQNCT ISIQDYEVFR CEDSLDERKI KGVIELRKSL LSALRTYEPY
   181  GSLVQQIRIL LLGPIGAGKS SFFNSVRSVF QGHVTHQALV GTNTTGISEK YRTYSIRDGK
   241  DGKYLPFILC DSLGLSEKEG GLCRDDIFYI LNGNIRDRYQ FNPMESIKLN HHDYIDSPSL
   301  KDRIHCVAFV FDASSIQYFS SQMIVKIKRI RRELVNAGVV HVALLTHVDS MDLITKGDLI
   361  EIERCEPVRS KLEEVQRKLG FALSDISVVS NYSSEWELDP VKDVLILSAL RRMLWAADDF
   421  LEDLPFEQIG NLREEIINCA QGKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFI44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 95 nTPM
salivary gland: 67 nTPM
spleen: 61 nTPM
gallbladder: 43 nTPM
epididymis: 33 nTPM
lung: 29 nTPM

Single-cell type

vascular endothelial cells: 79 nCPM
oligodendrocyte progenitor cells: 77 nCPM
kupffer cells: 64 nCPM
macrophages: 62 nCPM
microglia: 57 nCPM
innate lymphoid cells: 54 nCPM

Immune cell

classical monocyte: 16 nTPM
intermediate monocyte: 15 nTPM
MAIT T-cell: 14 nTPM
memory CD4 T-cell: 10 nTPM
non-classical monocyte: 8.4 nTPM
NK-cell: 7.9 nTPM

Brain region

medulla oblongata: 29 nTPM
spinal cord: 23 nTPM
pons: 17 nTPM
white matter: 15 nTPM
thalamus: 15 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: -1.3
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFI44 as an antibody target. Whether an autoantibody or antibody against IFI44 could matter depends on whether native IFI44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFI44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFI44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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