Seroatlas · Human Serome Atlas

GIMAP1

GTPase IMAP family member 1

Also known as: GIMA1_HUMAN, HIMAP1, IAN2, IMAP1, IMAP38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWP7
Gene: GIMAP1
Ensembl: ENSG00000213203
Chromosome: 7
Canonical length: 306 aa
Protein class: Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene is thought to be involved in the differentiation of T helper (Th) cells of the Th1 lineage, and the related mouse gene has been shown to be critical for the development of mature B and T lymphocytes. Read-through transcription exists between this gene and the downstream GIMAP5 (GTPase, IMAP family member 5) gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q8WWP7|GIMAP1
     1  MGGRKMATDE ENVYGLEENA QSRQESTRRL ILVGRTGAGK SATGNSILGQ RRFFSRLGAT
    61  SVTRACTTGS RRWDKCHVEV VDTPDIFSSQ VSKTDPGCEE RGHCYLLSAP GPHALLLVTQ
   121  LGRFTAQDQQ AVRQVRDMFG EDVLKWMVIV FTRKEDLAGG SLHDYVSNTE NRALRELVAE
   181  CGGRVCAFDN RATGREQEAQ VEQLLGMVEG LVLEHKGAHY SNEVYELAQV LRWAGPEERL
   241  RRVAERVAAR VQRRPWGAWL SARLWKWLKS PRSWRLGLAL LLGGALLFWV LLHRRWSEAV
   301  AEVGPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIMAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

spleen: 23 nTPM
lymph node: 18 nTPM
appendix: 10 nTPM
adipose tissue: 9.9 nTPM
heart muscle: 9.7 nTPM
lung: 8.7 nTPM

Single-cell type

microglia: 37 nCPM
nk-cells: 3.2 nCPM
vascular endothelial cells: 3 nCPM
monocytes: 2.1 nCPM
t-cells: 2 nCPM
hematopoietic stem cells: 1 nCPM

Immune cell

naive CD4 T-cell: 68 nTPM
naive CD8 T-cell: 56 nTPM
memory CD8 T-cell: 54 nTPM
MAIT T-cell: 51 nTPM
memory CD4 T-cell: 48 nTPM
gdT-cell: 44 nTPM

Brain region

thalamus: 4.5 nTPM
medulla oblongata: 4.3 nTPM
spinal cord: 4.2 nTPM
pons: 4 nTPM
white matter: 3.6 nTPM
midbrain: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0.4
gnomAD missense Z: 0.87
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIMAP1 as an antibody target. Whether an autoantibody or antibody against GIMAP1 could matter depends on whether native GIMAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIMAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIMAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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